Author | Pereira, Marcos Donizete Peliçon | pt_BR |
Author | Ferreira, Matheus R. | pt_BR |
Author | Messiano, Gisele Barald | pt_BR |
Author | Cerávolo, Isabela Penna | pt_BR |
Author | Lopes, Lucia Maria Xavier | pt_BR |
Author | Krettli, Antoniana Ursine | pt_BR |
Access date | 2016-07-07T13:03:47Z | pt_BR |
Access date | 2016-07-08T18:43:30Z | |
Available date | 2016-07-07T13:03:47Z | pt_BR |
Available date | 2016-07-08T18:43:30Z | |
Document date | 2015 | |
Citation | PEREIRA, Marcos Donizete Peliçon et al. Aryltetralols from Holostylis reniformis and syntheses of lignan analogous. Phytochemistry Letters, v. 13, p. 200–205, 2015. | pt_BR |
ISSN | 1874-3900 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/14811 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Title | Aryltetralols from Holostylis reniformis and syntheses of lignan analogous | pt_BR |
Type | Article | |
DOI | 10.1016/j.phytol.2015.06.001 | pt_BR |
Abstract | Two new lignans, an aryltetralol and its methyl ether analogous, were isolated from Holostylis reniformis (Aristolochiaceae) together with futokadsurin C and (−)-8′-epi-aristoligone. The latter was also obtained as an enantiomeric mixture by synthesis and was transformed into aryltetralols and aryltetralenes that were subjected to chiral-HPLC separations. The compound structures were determined by spectroscopic methods. Several of these lignans had their antiplasmodial activity (against Plasmodium falciparum, W2 clone, anti-HRPII) and toxicity to mammalian kidney cells (MDL50) evaluated. (−)-Cyclogalgravin and (−)-aristoligol exhibited activity (IC50 ∼ 10.8 and 8.4 μM, respectively), the latter exhibited lower toxicity. | pt_BR |
Affilliation | Universidade Estadual de São Paulo. Instituto de Quimica. Araraquara, SP, Brasil. | pt_BR |
Affilliation | Universidade Estadual de São Paulo. Instituto de Quimica. Araraquara, SP, Brasil. | pt_BR |
Affilliation | Universidade Estadual de São Paulo. Instituto de Quimica. Araraquara, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Estadual de São Paulo. Instituto de Quimica. Araraquara, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Holostylis reniformis | pt_BR |
Subject | Aristolochiaceae | pt_BR |
Subject | Lignans | pt_BR |
Subject | Aryltetralol | pt_BR |
Subject | Arytetralene | pt_BR |
Subject | Antiplasmodial activity | pt_BR |