| Author | Heringer, Manoela | |
| Author | Nogueira, Rita Maria R. | |
| Author | Filippis, Ana Maria Bispo de | |
| Author | Lima, Monique R. Q. | |
| Author | Faria, Nieli R. C. | |
| Author | Nunes, Priscila C. G. | |
| Author | Nogueira, Fernanda B, | |
| Author | Santos, Flávia B. dos | |
| Access date | 2016-07-07T17:31:56Z | pt_BR |
| Access date | 2016-07-08T18:49:10Z | |
| Available date | 2016-07-07T17:31:56Z | pt_BR |
| Available date | 2016-07-08T18:49:10Z | |
| Document date | 2015 | |
| Citation | HERINGER, Manoela; et al. Impact of the emergence and re-emergence of different dengue viruses’ serotypes in Rio de Janeiro, Brazil, 2010 to 2012. Trans R Soc Trop Med Hyg., v.109, n.4, p.268-274, Apr. 2015. | pt_BR |
| ISSN | 0035-9203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14827 | |
| Language | por | pt_BR |
| Publisher | The Royal Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Dengue | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Casos fatais | pt_BR |
| Subject in Portuguese | Diagnóstico laboratorial | pt_BR |
| Subject in Portuguese | Vigilância | pt_BR |
| Subject in Portuguese | Rio de Janeiro | pt_BR |
| Title | Impact of the emergence and re-emergence of different dengue viruses’ serotypes in Rio de Janeiro, Brazil, 2010 to 2012 | pt_BR |
| Type | Article | |
| DOI | 10.1093/trstmh/trv006 | pt_BR |
| Abstract | Abstract
BACKGROUND:
Rio de Janeiro (RJ) has been of major importance for the epidemiology of dengue viruses (DENVs) in Brazil. After the DENV 1-4 introductions in 1986, 1990, 2000 and 2011, respectively, the state has suffered explosive epidemics. We aimed to describe laboratorial, epidemiological and clinical aspects due to the emergence and re-emergence of distinct DENV in a 2-year period.
METHODS:
Suspected dengue cases (n=2833), including 190 fatal cases, were submitted to virus isolation, RT-PCR and non-structural 1 (NS1) antigen capture ELISA, IgM antibody-capture (MAC)-ELISA and IgG-ELISA.
RESULTS:
Case confirmation was 47.5%. MAC-ELISA confirmed 32.6% of the cases, RT-PCR confirmed 56.3%; DENV was recovered in 33.1% of samples inoculated and NS1 ELISA confirmed 27.5% of the cases. DENV-2 was prevalent in 2010, DENV-1 in 2011 and DENV-4 in 2012. Individuals infected by DENV-3 and over 65 years-old, and children 15 years-old and under infected by DENV-2 had a significantly higher risk of developing a severe disease. Fatal cases confirmed (n=67) were due to DENV-1 (26.8%), DENV-2 (14.9%), DENV-3 (2.9%) and DENV-4 (7.4%).
CONCLUSIONS:
It has been shown here that viral emergences or re-emergences may play different roles in the disease epidemiology, especially when many serotypes co-circulate. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Dengue | pt_BR |
| Subject | Fatal cases | pt_BR |
| Subject | Laboratorial diagnosis | pt_BR |
| Subject | Surveillance | pt_BR |
| Subject | Rio de Janeiro | pt_BR |
| e-ISSN | 1878-3503 | pt_BR |
