| Author | Silva, Adriano Gomes | |
| Author | Valverde, Joanna Gardel | |
| Author | Romão, Raquel Peralva Ribeiro | |
| Author | Pereira, Rosa Maria Plácido | |
| Author | Cruz, Alda Maria da | |
| Access date | 2016-07-14T16:53:17Z | |
| Available date | 2016-07-14T16:53:17Z | |
| Document date | 2013 | |
| Citation | SILVA, Adriano Gomes; et al. Golden hamster (Mesocricetus auratus) as an experimental model for Leishmania (Viannia) braziliensis infection. Parasitology, v.140, n.06, p.771-779, May 2013. | pt_BR |
| ISSN | 0031-1820 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14892 | |
| Language | eng | pt_BR |
| Publisher | Cambridge University Press | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Resultado clínico | pt_BR |
| Subject in Portuguese | Leishmaniose tegumentar americana | pt_BR |
| Subject in Portuguese | Hamster dourado | pt_BR |
| Title | Golden hamster (Mesocricetus auratus) as an experimental model for Leishmania (Viannia) braziliensis infection | pt_BR |
| Type | Article | |
| DOI | 10.1017/S0031182012002156 | |
| Abstract | The lack of an adequate model for Leishmania (Viannia) braziliensis infection is a limiting factor for studying American tegumentary leishmaniasis (ATL). The golden hamster (Mesocricetus auratus) is a promising model because besides being highly susceptible to dermotropic Leishmania infection, the lesions are very similar to cutaneous leishmaniasis (CL) in humans. However, different Leishmania isolates or species and/or protocols have resulted in different outcomes, whereas no study has evaluated the reproducibility of L. braziliensis infection in this model. The natural history of L. braziliensis infection in 34 hamsters was evaluated by using a single parasite isolate in 8 independent experiments under similar experimental conditions. Clinical, histological and immunological analyses were performed. The hamsters presented skin ulcers similar to those observed in ATL. The intra-experiment lesion increment tended to show an intermediary variance. Histological analysis of infected skins showed granulomatous reaction, scarce amastigotes, and Schaumann's bodies. Blood lymphocytes proliferated in response to leishmanial antigens. The severity of the infection was positively correlated to spleen weight, and the titres of anti-Leishmania IgG antibodies. Our findings indicate that the hamster is an appropriate model for immunopathogenesis studies of CL caused by L. braziliensis, supporting its use in clinical, vaccine and chemotherapy experimental protocols. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Golden hamster | pt_BR |
| Subject | American tegumentary leishmaniasis | pt_BR |
| Subject | Leishmania (Vianna) braziliensis | pt_BR |
| Subject | immunoglobulin | pt_BR |
| Subject | Lymphocyte | pt_BR |
| Subject | Clinical outcome | pt_BR |
| Subject | Histopathology | pt_BR |
| DeCS | Mesocricetus | pt_BR |
| DeCS | Leishmania braziliensis | pt_BR |
| DeCS | Imunoglobulina | pt_BR |
| DeCS | Linfócitos | pt_BR |
| DeCS | Patologia | pt_BR |
| e-ISSN | 1469-8161 | |
| Embargo date | 2030-01-01 | |
