| Autor | Gómez, Mariela Martínez | |
| Autor | Silva, Marcelle Figueira Marques da | |
| Autor | Zeller, Mark | |
| Autor | Heylen, Elisabeth | |
| Autor | Matthijnssens, Jelle | |
| Autor | Ichihara, Maria Yuri Travassos | |
| Autor | Rose, Tatiana Lundgren | |
| Autor | Volotão, Eduardo de Mello | |
| Autor | Leite, José Paulo Gagliardi | |
| Data de acesso | 2016-07-19T13:25:17Z | |
| Data de disponibilização | 2016-07-19T13:25:17Z | |
| Data do publicação | 2013 | |
| Citação | GÒMEZ, Mariela Martínez; et al. Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix™. Infection, Genetics and Evolution, v.19, p.395-402, Oct. 2013. | pt_BR |
| ISSN | 1567-1348 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14972 | |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Direito Autoral | restricted access | |
| Palavras-chave | Análise filogenética | pt_BR |
| Palavras-chave | Rotavírus do grupo A | pt_BR |
| Palavras-chave | Análise de genoma completo | pt_BR |
| Título | Phylogenetic analysis of G1P[6] group A rotavirus strains detected in Northeast Brazilian children fully vaccinated with Rotarix™ | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.1016/j.meegid.2013.03.028 | |
| Resumo em Inglês | In 2009 the World Health Organization recommended the use of group A rotavirus (RVA) vaccines in all national immunization programs (NIPs) in order to control severe RVA gastroenteritis disease. In Brazil, Rotarix™ was introduced in the NIP in March 2006, and a significant reduction in mortality rates among children ≤ 5 years old was observed, especially in the Northern and Northeastern Brazil. In the current study the 11 gene segments of six Brazilian G1P[6] RVA strains, isolated in 2009 and 2010 from vaccinated children, were analyzed in order to investigate if the genetic composition of these strains might help to elucidate why they were able to cause acute gastroenteritis in vaccinated children. All six Brazilian RVA strains revealed a complete Wa-like genotype constellation: G1-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1. Phylogenetic analysis showed that all six strains were nearly identical and showed a close genetic relationship with contemporary typical human Wa-like RVA strains. These results suggests that the fact that these strains were able to cause acute gastroenteritis in vaccinated children is likely not due to the genetic background of the strains, but rather to other factors such as host relating factors, co-infecting pathogens or vaccine efficacy. P[6] RVA strains are detected rather occasionally in humans in most regions of the world, except for South Asia and Sub-Saharan Africa. However, recently two studies conducted in Brazil showed the circulation of G12P[6] and G2P[6]. This is the first report on the detection and complete genome analyses of G1P[6] RVA strains in Brazil. Surveillance studies will be crucial to further investigate the prevalence of this genotype in the Brazilian population, and the efficacy of current licensed vaccines, which do not contain the P[6] genotype. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | University of Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium. | pt_BR |
| Afiliação | University of Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium. | pt_BR |
| Afiliação | University of Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium. | pt_BR |
| Afiliação | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras-chave em inglês | Group A rotavirus | pt_BR |
| Palavras-chave em inglês | G1P[6]; Rotarix™ | pt_BR |
| Palavras-chave em inglês | Phylogenetic analysis | pt_BR |
| Palavras-chave em inglês | Complete genome analysis | pt_BR |
| e-ISSN | 1567-7257 | |
| Data de embargo | 2030-01-01 | |
