| Author | Paploski, Igor Adolfo Dexheimer | pt_BR |
| Author | Prates, Ana Paula Pitanga Barbuda | pt_BR |
| Author | Cardoso, Cristiane Wanderley | pt_BR |
| Author | Kikuti, Mariana | pt_BR |
| Author | Silva, Monaise Madalena Oliveira O. | pt_BR |
| Author | Waller, Lance A. | pt_BR |
| Author | Reis, Mitermayer Galvão dos | pt_BR |
| Author | Kitron, Uriel | pt_BR |
| Author | Ribeiro, Guilherme de Sousa | pt_BR |
| Access date | 2016-05-20T13:45:22Z | pt_BR |
| Access date | 2016-07-22T13:10:45Z | |
| Available date | 2016-05-20T13:45:22Z | pt_BR |
| Available date | 2016-07-22T13:10:45Z | |
| Document date | 2016 | |
| Citation | PAPLOSKI, Igor Adolfo Dexheimer et al. Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barré Syndrome, and Microcephaly, Salvador, Brazil. Emerging Infectious Diseases, v. 22, n. 8, Aug. 2016. | pt_BR |
| ISSN | 1080-6040 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15068 | |
| Language | eng | pt_BR |
| Publisher | Centers for Disease Control and Prevention | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Zika vírus | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Saúde pública | pt_BR |
| Subject in Portuguese | Malformações congênitas | pt_BR |
| Subject in Portuguese | Emergência | pt_BR |
| Subject in Portuguese | Síndrome de Guillain-Barré | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Feminino | pt_BR |
| Subject in Portuguese | Primeiro trimestre dsa gravidez | pt_BR |
| Title | Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barré Syndrome, and Microcephaly, Salvador, Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3201/eid2208.160496 | pt_BR |
| Abstract | Zika virus infection emerged as a public health emergency after increasing evidence for its association with neurologic disorders and congenital malformations. In Salvador, Brazil, outbreaks of acute exanthematous illness (AEI) attributed to Zika virus, Guillain-Barré syndrome (GBS), and microcephaly occurred in 2015. We investigated temporal correlations and time lags between these outbreaks to identify a common link between them by using epidemic curves and time series cross-correlations. Number of GBS cases peaked after a lag of 5–9 weeks from the AEI peak. Number of suspected cases of microcephaly peaked after a lag of 30–33 weeks from the AEI peak, which corresponded to time of potential infections of pregnant mothers during the first trimester. These findings support the association of GBS and microcephaly with Zika virus infection and provide evidence for a temporal relationship between timing of arboviral infection of pregnant women during the first trimester and birth outcome. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Emory University. Atlanta, Georgia, USA. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Emory University. Atlanta, Georgia, USA / Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
