Author | Espindola, Milena Sobral | pt_BR |
Author | Lima, Leonardo Judson Galvão de | pt_BR |
Author | Soares, Luana Silva | pt_BR |
Author | Cacemiro, Maira da Costa | pt_BR |
Author | Zambuzi, Fabiana A Albani | pt_BR |
Author | Gomes, Matheus de Souza | pt_BR |
Author | Amaral, Laurence Rodrigues | pt_BR |
Author | Bollela, Valdes Roberto | pt_BR |
Author | Martins Filho, Olindo Assis | pt_BR |
Author | Frantz, Fabiani G. | pt_BR |
Access date | 2016-07-08T19:23:26Z | pt_BR |
Access date | 2016-07-22T13:23:08Z | |
Available date | 2016-07-08T19:23:26Z | pt_BR |
Available date | 2016-07-22T13:23:08Z | |
Document date | 2015 | |
Citation | ESPINDOLA, Milena Sobral et al. Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients. PLoS One, v. 10, n. 12, p. 1-17, 2015. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15083 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0145261 | pt_BR |
Abstract | BACKGROUND: Successful highly active antiretroviral therapy (HAART) has changed the outcome of AIDS patients worldwide because the complete suppression of viremia improves health and prolongs life expectancy of HIV-1+ patients. However, little attention has been given to the immunological profile of patients under distinct HAART regimens. This work aimed to investigate the differences in the immunological pattern of HIV-1+ patients under the first- or second-line HAART in Brazil.
METHODS: CD4+ T cell counts, Viral load, and plasma concentration of sCD14, sCD163, MCP-1, RANTES, IP-10, IL-1β, IL-6, TNF-α, IL-12, IFN-α, IFN-γ, IL-4, IL-5, and IL-10 were assessed for immunological characterization of the following clinical groups: Non-infected individuals (NI; n = 66), HIV-1+ untreated (HIV; n = 46), HIV-1+ treated with first-line HAART (HAART 1; n = 15); and HIV-1+ treated with second-line HAART (HAART 2; n = 15).
RESULTS: We found that the immunological biosignature pattern of HAART 1 is similar to that of NI individuals, especially in patients presenting slow progression of the disease, while patients under HAART 2 remain in a moderate inflammatory state, which is similar to that of untreated HIV patients pattern. Network correlations revealed that differences in IP-10, TNF-α, IL-6, IFN-α, and IL-10 interactions were primordial in HIV disease and treatment. Heat map and decision tree analysis identified that IP-10>TNF-α>IFN-α were the best respective HAART segregation biomarkers.
CONCLUSION: HIV patients in different HAART regimens develop distinct immunological biosignature, introducing a novel perspective into disease outcome and potential new therapies that consider HAART patients as a heterogeneous group. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Biomarcadores para Diagnostico e Monitoramento. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | pt_BR |
Subject | Antiretroviral Therapy | pt_BR |
Subject | Highly Active | pt_BR |
Subject | Disease Progression | pt_BR |
Subject | HIV Infections/immunology | pt_BR |