| Author | Araujo, Abelardo Q. C. | |
| Author | Silva, Marcus Tulius T. | |
| Author | Araujo, Alexandra P. Q. C. | |
| Access date | 2016-08-03T13:08:57Z | |
| Available date | 2016-08-03T13:08:57Z | |
| Document date | 2016 | |
| Citation | ARAUJO, Abelardo Q. C.; SILVA, Marcus Tulius T.; ARAUJO, Alexandra P. Q. C. Zika virus-associated neurological disorders: a review. Brain a Journal of Neurology, p.1-9, 2016. | pt_BR |
| ISSN | 0006-8950 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15190 | |
| Description | We are grateful to Professor William W. Hall, MD, PhD (CRID, University College Dublin, Ireland) for his useful suggestions. We thank Dr. Lara Brandão, MD (Clinica Radiologica Felipe Mattoso, Rio de Janeiro, Brazil), for the MRI report of the microcephaly case. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Title | Zika virus-associated neurological disorders: a review | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/brain/aww158 | |
| Abstract | Zika virus, an arbovirus transmitted by mosquitoes of the Aedes species, is now rapidly disseminating throughout the Americas and the ongoing Brazilian outbreak is the largest Zika virus epidemic so far described. In addition to being associated with a non-specific acute febrile illness, a number of neurological manifestations, mainly microcephaly and Guillain-Barré syndrome, have been associated with infection. These with other rarer neurological conditions suggest that Zika virus, similar to other flaviviruses, is neuropathogenic. The surge of Zika virus-related microcephaly cases in Brazil has received much attention and the role of the virus in this and in other neurological manifestations is growing. Zika virus has been shown to be transmitted perinatally and the virus can be detected in amniotic fluid, placenta and foetus brain tissue. A significant increase in Guillain-Barré syndrome incidence has also been reported during this, as well as in previous outbreaks. More recently, meningoencephalitis and myelitis have also been reported following Zika virus infection. In summary, while preliminary studies have suggested a clear relationship between Zika virus infection and certain neurological conditions, only longitudinal studies in this epidemic, as well as experimental studies either in animal models or in vitro, will help to better understand the role of the virus and the pathogenesis of these disorders. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Neurologia Deolindo Couto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Arbovirus | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Guillain-Barré syndrome | pt_BR |
| Subject | Neurological complications | pt_BR |
| Subject | ZIKV | pt_BR |
| e-ISSN | 1460-2156 | |
