| Author | Peixoto, Maíra | |
| Author | Mascarenhas, Lays | |
| Author | Cunha, André | |
| Author | Dutra, Margarida | |
| Author | Miranda, Eva | |
| Author | Silva, Ivo | |
| Author | Costa, Sandra | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Cunha, Andréa | |
| Access date | 2016-08-03T16:41:33Z | |
| Available date | 2016-08-03T16:41:33Z | |
| Document date | 2012 | |
| Citation | PEIXOTO, M. et al. Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene. Antiviral Therapy, v. 17, p. 585-588, 2016. | pt_BR |
| ISSN | 1359-6535 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15192 | |
| Sponsorship | Fundação de Amparo a Pesquisa do Estado da Bahia - FAPESB; Conselho Nacional de Pesquisa - CNPq | pt_BR |
| Language | eng | pt_BR |
| Publisher | International Medical Press | pt_BR |
| Rights | open access | pt_BR |
| Title | Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3851/IMP1938 | |
| Abstract | Ganciclovir (GCV) is the first therapeutic choice for prevention and treatment of active cytomegalovirus (CMV) infection in solid organ transplant recipients in Bahia state, Brazil. Prolonged and repeated GCV therapy may result in drug-resistant virus, associated with progressive and disseminated disease. We present a case report of a young male kidney recipient, who was CMV-seronegative with a CMV-seropositive donor (D(+)/R(-)), and who developed clinical GCV resistance, confirmed by mutation in viral UL97 phosphotransferase responsible for GCV activation. Under prophylactic therapy with intravenous GCV for 6 weeks post-transplantation, he developed severe anaemia and hepatic enzyme increases, probably due to drug side effects. At this moment, the drug was discontinued and he started to be monitored by pp65 antigen test. At week 10 post-transplantation, he presented fever, myalgia, thrombocytopenia and neutropaenia, with a positive CMV antigen test. During treatment with intravenous GCV, antigenaemia assay demonstrated a higher number of positive cells, requiring GCV at higher doses. Pre-emptive therapy lasted for 31 days and he started the maintenance therapy with oral GCV. However, antigenaemia assay demonstrated an extremely high number of positive cells, and he was rehospitalized and prescribed intravenous GCV. Severe leukopaenia led to GCV interruption, but immunosuppressive dose reduction helped to control the active CMV infection. GCV-resistant CMV infection resulted in increased morbidity, rehospitalization episodes and increased costs; therefore, implementation of resistance diagnostic tests in the transplantation routine is of great importance. We documented the first case of GCV-resistant CMV infection due to the L595S mutation in UL97 phosphotransferase gene in a kidney recipient from Bahia state, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital Portuguese. Transplantation Service Department. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital Portuguese. Service of Nephrology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital Portuguese. Service of Nephrology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Hospital Portuguese. Service of Nephrology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Laboratório de Diagnóstico Molecular de Doenças Infecciosas. Campinas, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Subject | Antiviral agents | pt_BR |
| Subject | Cytomegalovirus | pt_BR |
| Subject | Cytomegalovirus infection | pt_BR |
| Subject | Drug Resistance, viral | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Humans | pt_BR |
| Subject | Kidney transplantation | pt_BR |
| Subject | Male | pt_BR |
