| Author | Mave, Vidya | |
| Author | Erlandson, Kristine M | |
| Author | Gupte, Nikhil | |
| Author | Balagopal, Ashwin | |
| Author | Asmuth, David M | |
| Author | Campbell, Thomas B | |
| Author | Smeaton, Laura | |
| Author | Kumarasamy, Nagalingeswaran | |
| Author | Hakim, James | |
| Author | Santos, Breno | |
| Author | Riviere, Cynthia | |
| Author | Hosseinipour, Mina C | |
| Author | Sugandhavesa, Patcharaphan | |
| Author | Infante, Rosa | |
| Author | Pillay, Sandy | |
| Author | Cardoso, Sandra Wagner | |
| Author | Tripathy, Srikanth | |
| Author | Mwelase, Noluthando | |
| Author | Berendes, Sima | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Thomas, David L | |
| Author | Bollinger, Robert C | |
| Author | Gupta, Amita | |
| Access date | 2016-08-10T14:12:08Z | |
| Available date | 2016-08-10T14:12:08Z | |
| Document date | 2016 | |
| Citation | MAVE, V. et al. Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults. • Journal of Infectious Diseases, v. 214, p. 65-72, 2016. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15224 | |
| Description | ACTG PEARLS and NWCS 319 Study Team | pt_BR |
| Language | eng | pt_BR |
| Publisher | University of Chicago Press | pt_BR |
| Rights | open access | pt_BR |
| Title | Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/infdis/jiw096 | |
| Abstract | Background. Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods. Among a random virologically suppressed participants of the Prospective Evaluation of Antiretrovirals in Resource-
Limited Settings trial, inflammatory markers were measured at weeks 0, 24, and 48 after antiretroviral therapy (ART) initiation. Associations
between both baseline and change in body mass index (BMI; calculated as the weight in kilograms divided by the height in
meters squared) and changes in inflammation markers were assessed using random effects models.
Results. Of 246 participants, 27% were overweight/obese (BMI, ≥ 25), and 8% were underweight (BMI < 18.5) at baseline.
After 48 weeks, 37% were overweight/obese, and 3% were underweight. While level of many inflammatory markers decreased 48
weeks after ART initiation in the overall group, the decrease in C-reactive protein (CRP) level was smaller in overweight/obese participants
(P = .01), and the decreases in both CRP (P = .01) and interleukin 18 (P = .02) levels were smaller in underweight participants.
Each 1-unit gain in BMI among overweight/obese participants was associated with a 0.02-log10 increase in soluble CD14 level
(P = .05), while each 1-unit BMI gain among underweight participants was associated with a 9.32-mg/L decrease in CRP level
(P = .001).
Conclusions. Being either overweight or underweight at ART initiation was associated with heightened systemic inflammation.
While weight gain among overweight/obese persons predicted increased inflammation, weight gain among underweight persons
predicted reduced inflammation. | pt_BR |
| Affilliation | Johns Hopkins University-BJ. Medical College Clinical Research Site. Pune, India / Johns Hopkins University. Division of Infectious Diseases. Baltimore, Maryland | pt_BR |
| Affilliation | University of Colorado Denver. Department of Medicine. Denver, Aurora | pt_BR |
| Affilliation | Johns Hopkins University-BJ. Medical College Clinical Research Site. Pune, India / Johns Hopkins University. Division of Infectious Diseases. Baltimore, Maryland | pt_BR |
| Affilliation | Johns Hopkins University. Division of Infectious Diseases. Baltimore, Maryland | pt_BR |
| Affilliation | University California Davis. Department of Medicine. Sacramento, USA | pt_BR |
| Affilliation | University of Colorado Denver. Department of Medicine. Denver, Aurora | pt_BR |
| Affilliation | Harvard T. H. Chan School of Public Health. Boston, Massachusetts | pt_BR |
| Affilliation | Y. R. Gaitonde Center for AIDS Research and Education. Chennai, India | pt_BR |
| Affilliation | University of Zimbabwe. Harare | pt_BR |
| Affilliation | Hospital Nossa Senhora de Conceição. Porto Alegre, RS, Brasil | pt_BR |
| Affilliation | Les Centres GHESKIO. Port-Au-Prince, Haiti | pt_BR |
| Affilliation | University of North Carolina Project. Lilongwe, Malawi | pt_BR |
| Affilliation | Research Institute for Health Sciences. Chiang Mai, Thailand | pt_BR |
| Affilliation | IMPACTA Peru. San Miguel | pt_BR |
| Affilliation | Durban University of Technology. Durban International Clinical Research Site. South Africa | pt_BR |
| Affilliation | Fundacao Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. STD/AIDS Clinical Research Laboratory. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | National AIDS Research Institute. Pune, India | pt_BR |
| Affilliation | University of Witwatersrand. Department of Medicine. Johannesburg, South Africa | pt_BR |
| Affilliation | Malawi College of Medicine-Johns Hopkins University Research Project. Blantyre / Liverpool School of Tropical Medicine. United Kingdom | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação José Silveira. Instituto Brasileiro para a Investigação da Tuberculose. Salvador, BA, Brasil | pt_BR |
| Affilliation | Johns Hopkins University. Division of Infectious Diseases. Baltimore, Maryland | pt_BR |
| Affilliation | Johns Hopkins University. Division of Infectious Diseases. Baltimore, Maryland | pt_BR |
| Affilliation | Johns Hopkins University-BJ. Medical College Clinical Research Site. Pune, India / Johns Hopkins University. Division of Infectious Diseases. Baltimore, Maryland | pt_BR |
| Subject | Immune activation/inflammation | pt_BR |
| Subject | Body mass index | pt_BR |
| Subject | HIV/AIDS | pt_BR |
| Subject | HAART clinical outcomes | pt_BR |
| Subject | Noncommunicable diseases | pt_BR |
