| Author | Cestari, Igor | |
| Author | Evans-Osses, Ingrid | |
| Author | Schlapbach, Luregn J. | |
| Author | Reason, Iara de Messias | |
| Author | Ramirez, Marcel I. | |
| Access date | 2016-08-25T17:14:51Z | |
| Available date | 2016-08-25T17:14:51Z | |
| Document date | 2013 | |
| Citation | CESTARI, Igor; et al. Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites. Molecular Immunology, v.53, n.4, p.328-334, Apr. 2013. | pt_BR |
| ISSN | 0161-5890 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15406 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Sistema de complemento | pt_BR |
| Subject in Portuguese | Imunidade inata | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Tripanossomíase | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Hospedeiros de parasitas | pt_BR |
| Title | Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.molimm.2012.08.015 | |
| Abstract | Studies in the past decade have demonstrated a crucial role for the complement lectin pathway in host defence against protozoan microbes. Recognition of pathogen surface molecules by mannan-binding lectin and ficolins revealed new mechanisms of innate immune defence and a diversity of parasite strategies of immune evasion. In the present review, we will discuss the current knowledge of: (1) the molecular mechanism of lectin pathway activation by trypanosomes; (2) the mechanisms of complement evasion by trypanosomes; and (3) host genetic deficiencies of complement lectin pathway factors that contribute to infection susceptibility and disease progression. This review will focus on trypanosomatids, the parasites that cause Chagas disease, leishmaniasis and sleeping sickness (African trypanosomiasis). | pt_BR |
| Affilliation | Seattle Biomedical Research Institute, Seattle, WA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Mater Children's Hospital. Pediatric Critical Care Research Group. Brisbane, Australia. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Patologia Médica. Laboratório de Imunopatologia. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Complement system | pt_BR |
| Subject | Lectin pathway | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | Trypanosomiasis | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Parasite host cell interaction | pt_BR |
| Subject | Innate immunity | pt_BR |
| e-ISSN | 1872-914 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
