| Author | Santos, Ana Amélia Nunes | |
| Author | Figueira, Cláudio Pereira | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Costa, Federico | |
| Author | Ristow, Paula Carvalhal Lage von Buettner | |
| Access date | 2016-08-29T18:03:52Z | |
| Available date | 2016-08-29T18:03:52Z | |
| Document date | 2015 | |
| Citation | SANTOS, A. A. N. et al. Heterogenic colonization patterns by Leptospira interrogans in Rattus norvegicus from urban slums. Brazilian Journal of Microbiology, v. 46, n. 4, p. 1161-1164, 2015. | pt_BR |
| ISSN | 1517-8382 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15505 | |
| Sponsorship | Oswaldo Cruz Foundation (FIOCRUZ). Secretariat of Health Surveillance of the State of Bahia. National Institutes of Health. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Microbiologia | pt_BR |
| Rights | open access | pt_BR |
| Title | Heterogenic colonization patterns by Leptospira interrogans in Rattus norvegicus from urban slums | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S1517-838246420140873 | |
| Abstract | We evaluated the renal colonization by Leptospira interrogans in Rattus norvegicus (rats), as it is the major natural reservoir of urban leptospirosis. We caught 72 R. norvegicus, out of which 32 were found to be positive for L. interrogans by immunofluorescence assay. From these rats, we selected 17 and divided them into six groups based on the mass-age/sex. We performed the immunohistochemistry test against L. interrogans in the kidney sections of the rats and systematically counted the colonized tubules (CTs) in 20 fields. The proportion of positive fields varied from 5% to 95%. The number of CTs in 20 fields varied from 0.5 to 85.5. These differences were not related to age or sex of the animals. The characterization of leptospiral colonization patterns in the natural reservoirs is important to better understand the host-pathogen interactions in leptospirosis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Plataforma de Microscopia Eletrônica. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Núcleo de Epidemiologia e Bioestatística. Salvador, BA, Brasil / Yale School of Public Health. Division of Epidemiology of Microbial Diseases. Connecticut, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Biologia. Laboratório de Bacteriologia e Saúde. Salvador, BA, Brasil | pt_BR |
| Subject | Leptospira interrogans | pt_BR |
| Subject | Renal colonization | pt_BR |
| Subject | Natural reservoirs | pt_BR |
| Subject | Rattus norvegicus | pt_BR |
