| Author | Silva, Michele Costa | |
| Author | Barros, Lucas de Andrade | |
| Author | Garcia, Juberlan Silva | |
| Author | Neves, Renata Heisler | |
| Author | Silva, Rosângela Rodrigues | |
| Author | Silva, José Roberto Machado | |
| Author | Maldonado Júnior, Arnaldo | |
| Access date | 2016-08-30T16:22:47Z | |
| Available date | 2016-08-30T16:22:47Z | |
| Document date | 2012 | |
| Citation | SILVA, Michele Costa; et al. Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice. Experimental Parasitology, v.130, n.4, p.394-399, Apr. 2012. | pt_BR |
| ISSN | 0014-4894 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15542 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Schistosoma mansoni | pt_BR |
| Subject in Portuguese | Praziquantel | pt_BR |
| Subject in Portuguese | Hospedeiros não humanos | pt_BR |
| Subject in Portuguese | Suscetibilidade | pt_BR |
| Subject in Portuguese | Estudo parasitológico | pt_BR |
| Title | Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.exppara.2012.02.002 | |
| Abstract | The therapeutic effects of praziquantel (PZQ) against a Schistosoma mansoni isolate derived from Nectomys squamipes (isolate R) and a susceptible isolate (BH) were analyzed in Swiss mice by fecal egg counting, adult worm reduction and oogram pattern. Infected mice were orally administrated with 62.5mg/kg (group 1), 125mg/kg (group 2), 250mg/kg (group 3) and 500mg/kg (group 4), each dose divided over 3 days (49, 50 and 51 days after infection). The data were analyzed using one-way analysis of variance (ANOVA). In regard to isolate R, no fecal eggs were observed with 250 mg/Kg and 500 mg/kg (p<0.05), whereas BH excretion reached zero with all doses. Mean worm burden reduction was significantly (p<0.05) higher at the two highest concentrations, regardless of isolate. At 62.5mg/kg, the percentage of immature eggs varied from 17% (isolate R) to 38% (isolate BH). At 125 mg/kg, the percentage of immature eggs varied from 20% (isolate R) to 16% (isolate BH). At 250 mg/kg, immature eggs dropped significantly to 1% (isolate R) and 4% (isolate BH). At 500 mg/kg, no immature eggs were found in isolate R, whereas in BH was 8%. No dosage significantly (p>0.05) affected the percentage of mature eggs, regardless of isolate. There was a large increase (p<0.001) in the percentages of dead eggs in all treated groups of 62% and 64% in groups 3 and 4, respectively (isolate R). The percentage of dead eggs rose from 34% (group 1) to 58% (group 3) in isolate BH. Although group 4 showed lowest increase in the percentage of dead eggs (46%), it was higher (p<0.001) compared to the 8% in the control. Our findings indicate that the wild isolate from N. squamipes is susceptible to PZQ. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Praziquantel | pt_BR |
| Subject | Susceptibility | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Non-human host | pt_BR |
| Subject | Nectomys squamipes | pt_BR |
| Subject | Parasitological study | pt_BR |
| e-ISSN | 1090-2449 | |
