| Autor | Soares, Cristiane N. | |
| Autor | Brasil, Patrícia | |
| Autor | Carrera, Raquel Medialdea | |
| Autor | Sequeira, Patricia | |
| Autor | Filippis, Ana Maria Bispo de | |
| Autor | Borges, Vitor A. | |
| Autor | Theophilo, Fernando | |
| Autor | Ellul, Mark A. | |
| Autor | Solomon, Tom | |
| Data de acesso | 2016-09-14T15:16:45Z | |
| Data de disponibilização | 2016-09-14T15:16:45Z | |
| Data do publicação | 2016 | |
| Citação | SOARES, Cristiane N. et al. Fatal encephalitis associated with Zika virus infection in an adult. Journal of Clinical Virology, v.83, p.63-65, 2016. | pt_BR |
| ISSN | 1386-6532 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15791 | |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Direito Autoral | open access | |
| Palavras-chave | Zika virus | pt_BR |
| Palavras-chave | Encefalite | pt_BR |
| Palavras-chave | Manifestações neurológicas | pt_BR |
| Título | Fatal encephalitis associated with Zika virus infection in an adult | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.1016/j.jcv.2016.08.297 | |
| Resumo em Inglês | Background: Zika virus (ZIKV) was first identified in the Americas in 2015, when an outbreak of an exanthematous
illness occurred in Brazil. Subsequentely, there was an increase of microcephaly cases, suggesting
an association between ZIKV and this neurological complication. Currently, ZIKV has been recognised as
causing a wide range of neurological complications including Guillain Barré syndrome, and myelitis.
Objectives: In this report, we describe the first fatal case of encephalitis in a 47 years old non pregnant
woman, infected during the Brazilian zika epidemic of 2016.
Study design: The diagnosis of encephalitis was determined by the presence of a disturbed level of
consciousness and focal neurological signs during an exanthemous viral infection.
Results: CSF analysis supported the diagnosis of viral encephalitis, revealing lymphocytic pleocytosis, a
high protein concentration, and the presence of IgM zika antibodies. RT-PCR analysis for ZIKV was positive
in the urine. A brain computed tomography showed massive brain swelling. Our case differs from previous
reports, because her neurological picture developed rapidly and in a very aggressive manner leading to
brain death after eleven days of admission.
Conclusion: In endemic areas, ZIKV should be considered as an aetiological agent in cases of encephalitis,
and clinicians should be aware of its potential severity. | pt_BR |
| Afiliação | Hospital Federal dos Servidores do Estado. Serviço de Neurologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | University of Liverpool. Institute of Infection and Global health. Liverpool, UK. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Hospital Badim. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Hospital Badim. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | University of Liverpool. Institute of Infection and Global Health. Liverpool, UK / University of Liverpool. Health Protection Research unit in Emerging and Zoonotic Infections. Liverpool, UK / Walton Centre NHS Foundation Trust. Liverpool, UK. | pt_BR |
| Afiliação | University of Liverpool. Institute of Infection and Global Health. Liverpool, UK / University of Liverpool. Health Protection Research unit in Emerging and Zoonotic Infections. Liverpool, UK / Walton Centre NHS Foundation Trust. Liverpool, UK. | pt_BR |
| Palavras-chave em inglês | Zika virus | pt_BR |
| Palavras-chave em inglês | Encephalitis | pt_BR |
| Palavras-chave em inglês | Neurological manifestations | pt_BR |
