Author | Passaes, Caroline Pereira Bittencourt | |
Author | Guimarães, Monick Lindenmeyer | |
Author | Cardoso, Sandra Wagner | |
Author | Pilotto, José Henrique | |
Author | Veloso, Valdiléa G. | |
Author | Grinsztejn, Beatriz | |
Author | Morgado, Mariza Gonçalves | |
Access date | 2016-09-15T14:07:06Z | |
Available date | 2016-09-15T14:07:06Z | |
Document date | 2012 | |
Citation | PASSAES, Caroline Pereira Bittencourt et al. Monitoring the Emergence of Resistance Mutations in Patients Infected With HIV-1 Under Salvage Therapy With Raltegravir in Rio de Janeiro, Brazil: A Follow-Up Study. Journal of Medical Virology, v. 84, p. 1869-1875, 2012. | pt_BR |
ISSN | 0146-6615 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15809 | |
Language | eng | pt_BR |
Publisher | wiley Online Library | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | HIV-1 | pt_BR |
Subject in Portuguese | Inibidores da integrase | pt_BR |
Subject in Portuguese | Raltegravir | pt_BR |
Subject in Portuguese | Mutações de resistência | pt_BR |
Title | Monitoring the emergence of resistance mutations in patients infected with HIV-1 under salvage therapy with raltegravir in Rio de Janeiro, Brazil: a follow-up study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/jmv.23409 | |
Abstract | The present study describes a follow-up of a prospective and observational cohort of patients infected with HIV-1 and treated with raltegravir for salvage therapy in Brazil. Two groups of patients were analyzed: switching from T20 to RAL (Group 1, n = 9) and salvage therapy containing RAL (Group 2, n = 10). Blood samples were drawn for CD4(+) T-cell counts and HIV-1 viral load determinations. Protease, reverse transcriptase, and integrase genotyping were performed at baseline and at the time of virologic failure. CD4(+) T-cells increased at 6 and 12 months in both groups; HIV-1 viral load was continuously suppressed for Group 1, and for Group 2 it significantly decreased after starting a RAL-containing regimen. Three out of 10 patients from Group 2 could not suppress HIV-1 viral load. The mutations Q148H + G140S were observed for two patients and for the third patient only mutations to PR/RT inhibitors were detected. The genotypic sensitivity score (GSS) was analyzed for all patients of Group 2 and both patients who developed resistance to raltegravir presented a GSS < 2.0 for the RAL-containing scheme, which could be associated to the lack of effectiveness of the proposed scheme. The present study describes, for the first time in Brazil, the close follow-up of a series of patients using a raltegravir-containing HAART, showing the safety of the enfuvirtide switch to RAL and the effectiveness of a therapeutic regimen with RAL in promoting immune reconstitution and suppressing HIV replication, as well as documenting the occurrence of resistance to integrase inhibitors in the country. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasill. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Integrase inhibitors | pt_BR |
Subject | Raltegravir | pt_BR |
Subject | Resistance mutations | pt_BR |
Subject | Enfuvirtide switches | pt_BR |
Subject | Brazil | pt_BR |
e-ISSN | 1096-9071 | |
Embargo date | 2030-01-01 | |