Author | Bello, Gonzalo | |
Author | Aulicino, Paula C. | |
Author | Ruchansky, Dora | |
Author | Guimarães, Monick L. | |
Author | Lopez-Galindez, Cecilio | |
Author | Casado, Concha | |
Author | Chiparelli, Hector | |
Author | Rocco, Carlos | |
Author | Mangano, Andrea | |
Author | Sen, Luisa | |
Author | Morgado, Mariza G. | |
Access date | 2016-09-21T17:35:28Z | |
Available date | 2016-09-21T17:35:28Z | |
Document date | 2010 | |
Citation | BELLO, Gonzalo; et al. Phylodynamics of HIV-1 Circulating Recombinant Forms 12_BF and 38_BF in Argentina and Uruguay. Retrovirology, v.7:22, 9p, 2010. | pt_BR |
ISSN | 1742-4690 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15892 | |
Language | eng | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HIV-1 | pt_BR |
Subject in Portuguese | Argentina | pt_BR |
Subject in Portuguese | Uruguai | pt_BR |
Subject in Portuguese | AIDS | pt_BR |
Title | Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/1742-4690-7-22 | |
Abstract | Background: Although HIV-1 CRF12_BF and CRF38_BF are two epidemiologically important recombinant lineages
circulating in Argentina and Uruguay, little is known about their population dynamics.
Methods: A total of 120 “CRF12_BF-like” and 20 “CRF38_BF-like” pol recombinant sequences collected in Argentina
and Uruguay from 1997 to 2009 were subjected to phylogenetic and Bayesian coalescent-based analyses to
estimate evolutionary and demographic parameters.
Results: Phylogenetic analyses revealed that CRF12_BF viruses from Argentina and Uruguay constitute a single
epidemic with multiple genetic exchanges among countries; whereas circulation of the CRF38_BF seems to be
confined to Uruguay. The mean estimated substitution rate of CRF12_BF at pol gene (2.5 × 10-3 substitutions/site/
year) was similar to that previously described for subtype B. According to our estimates, CRF12_BF and CRF38_BF
originated at 1983 (1978-1988) and 1986 (1981-1990), respectively. After their emergence, the CRF12_BF and
CRF38_BF epidemics seem to have experienced a period of rapid expansion with initial growth rates of around
1.2 year-1 and 0.9 year-1, respectively. Later, the rate of spread of these CRFs_BF seems to have slowed down
since the mid-1990s.
Conclusions: Our results suggest that CRF12_BF and CRF38_BF viruses were generated during the 1980s, shortly
after the estimated introduction of subtype F1 in South America (~1975-1980). After an initial phase of fast
exponential expansion, the rate of spread of both CRFs_BF epidemics seems to have slowed down, thereby
following a demographic pattern that resembles those previously reported for the HIV-1 epidemics in Brazil, USA,
and Western Europe. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital de Pediatría J P Garrahan. Laboratorio de Biología Celular y Retrovirus. CONICET. Buenos Aires, Argentina. | pt_BR |
Affilliation | Servicio Nacional de Laboratorios de Salud Publica - MSP. Laboratorio Nacional de Referencia VIH-SIDA. Montevideo, Uruguay. | pt_BR |
Affilliation | Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Virologia Molecular. Madrid, Spain. | pt_BR |
Affilliation | Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Virologia Molecular. Madrid, Spain. | pt_BR |
Affilliation | Servicio Nacional de Laboratorios de Salud Publica - MSP. Laboratorio Nacional de Referencia VIH-SIDA. Montevideo, Uruguay. | pt_BR |
Affilliation | Hospital de Pediatría J P Garrahan. Laboratorio de Biología Celular y Retrovirus. CONICET. Buenos Aires, Argentina. | pt_BR |
Affilliation | Hospital de Pediatría J P Garrahan. Laboratorio de Biología Celular y Retrovirus. CONICET. Buenos Aires, Argentina. | pt_BR |
Affilliation | Hospital de Pediatría J P Garrahan. Laboratorio de Biología Celular y Retrovirus. CONICET. Buenos Aires, Argentina. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Argentina | pt_BR |
Subject | Uruguay | pt_BR |
Subject | AIDS epidemic | pt_BR |
e-ISSN | 1742-4690 | |