| Author | Batista, Marcelo Meuser | |
| Author | Corrêa, José Raimundo | |
| Author | Carvalho, Vinícius Frias | |
| Author | Britto, Constança Felícia De Paoli de Carvalho | |
| Author | Moreira, Otacilio da Cruz | |
| Author | Batista, Marcos Meuser | |
| Author | Soares, Maurílio José | |
| Author | Farias Filho, Francisco Alves | |
| Author | Silva, Patrícia Machado R. E. | |
| Author | Lannes-Vieira, Joseli | |
| Author | Silva, Robson Coutinho | |
| Author | Pons, Andrea Henrique | |
| Access date | 2016-09-27T13:04:00Z | |
| Available date | 2016-09-27T13:04:00Z | |
| Document date | 2011 | |
| Citation | BATISTA, Marcelo Meuser; et al. Mast Cell Function and Death in Trypanosoma cruzi Infection. American Journal of Pathology, v.179, n.4, Oct. 2011. | pt_BR |
| ISSN | 0002-9440 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15957 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Mastócitos | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Cardiomiopatia | pt_BR |
| Title | Mast cell function and death in Trypanosoma cruzi infection | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.ajpath.2011.06.014 | |
| Abstract | Although the roles of mast cells (MCs) are essential in many inflammatory and fibrotic diseases, their role in Trypanosoma cruzi-induced cardiomyopathy is unexplored. In this study, we treated infected CBA mice with cromolyn, an MC stabilizer, and observed much greater parasitemia and interferon-γ levels, higher mortality, myocarditis, and cardiac damage. Although these data show that MCs are important in controlling acute infection, we observed MC apoptosis in the cardiac tissue and peritoneal cavity of untreated mice. In the heart, pericardial mucosal MC die, perhaps because of reduced amounts of local stem cell factor. Using RT-PCR in purified cardiac MCs, we observed that infection induced transcription of P2X(7) receptor and Fas, two molecules reportedly involved in cell death and inflammatory regulation. In gld/gld mice (FasL(-/-)), apoptosis of cardiac, but not peritoneal, MCs was decreased. Conversely, infection of P2X(7)(-/-) mice led to reduced peritoneal, but not cardiac, MC death. These data illustrate the immunomodulatory role played by MCs in T. cruzi infection and the complexity of molecular interactions that control inflammatory pathways in different tissues and compartments. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino, e Bioprodutos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de Brasília. Brasília, DF, Brasil / Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino, e Bioprodutos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | mast cells | pt_BR |
| Subject | inflammatory diseases | pt_BR |
| Subject | Cardiomiopathy | pt_BR |
| e-ISSN | 1525-2191 | |
