| Author | Teixeira, Raquel Lima de Figueiredo | |
| Author | Morato, Renata Gomes | |
| Author | Cabello, Pedro Hernan | |
| Author | Muniz, Ligia Mayumi Kitada | |
| Author | Moreira, Adriana da Silva Rezende | |
| Author | Kritsk, Afrânio Lineu | |
| Author | Mello, Fernanda Carvalho Queiroz | |
| Author | Suffys, Philip Noel | |
| Author | Miranda, Antonio Basílio de | |
| Author | Santos, Adalberto Rezende | |
| Access date | 2016-09-29T13:38:37Z | |
| Available date | 2016-09-29T13:38:37Z | |
| Document date | 2011 | |
| Citation | TEIXEIRA, Raquel Lima de Figueiredo; et al. Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients. Mem Inst Oswaldo Cruz, v.106, n.6, p.716-724, Sept. 2011. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15998 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Hepatotoxicity | pt_BR |
| Subject in Portuguese | Isoniazida | pt_BR |
| Title | Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients | pt_BR |
| Type | Article | |
| Abstract | Isoniazid (INH), one of the most important drugs used in antituberculosis (anti-TB) treatment, is also the major
drug involved in hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at
several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug-metabolising enzymes. Our goal was
to examine the polymorphisms in these enzymes as susceptibility factors to anti-TB drug-induced hepatitis in Brazilian
individuals. In a case-control design, 167 unrelated active tuberculosis patients from the University Hospital
of the Federal University of Rio de Janeiro, Brazil, were enrolled in this study. Patients with a history of anti-TB
drug-induced acute hepatitis (cases with an increase to 3 times the upper limit of normal serum transaminases and
symptoms of hepatitis) and patients with no evidence of anti-TB hepatic side effects (controls) were genotyped for
NAT2, CYP2E1, GSTM1 and GSTT1 polymorphisms. Slow acetylators had a higher incidence of hepatitis than
intermediate/rapid acetylators [22% (18/82) vs. 9.8% (6/61), odds ratio (OR), 2.86, 95% confidence interval (CI),
1.06-7.68, p = 0.04). Logistic regression showed that slow acetylation status was the only independent risk factor
(OR 3.59, 95% CI, 2.53-4.64, p = 0.02) for the occurrence of anti-TB drug-induced hepatitis during anti-TB treatment
with INH-containing schemes in Brazilian individuals. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Complexo Hospitalar. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Complexo Hospitalar. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Complexo Hospitalar. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Complexo Hospitalar. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | hepatotoxicity | pt_BR |
| Subject | tuberculosis | pt_BR |
| Subject | isoniazid | pt_BR |
| Subject | NAT2 | pt_BR |
| Subject | CYP2E1 | pt_BR |
| Subject | GSTMi | pt_BR |
| Subject | GSTT1 | pt_BR |
| e-ISSN | 1678-8060 | |
