| Author | Pinto Junior, Vitor Laerte Laerte | |
| Author | Rebelo, Maria Crisitna | |
| Author | Gomes, Rachel Novaes | |
| Author | Assis, Edson Fernandes de | |
| Author | Faria Neto, Hugo Caire Castro | |
| Author | Bóia, Márcio Neves | |
| Access date | 2016-10-04T17:32:58Z | |
| Available date | 2016-10-04T17:32:58Z | |
| Document date | 2011 | |
| Citation | PINTO JUNIOR, Vitor Laerte Laerte; et al. IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis. Braz J Infect Dis., v.15, n.2, p.156-158, 2011. | pt_BR |
| ISSN | 1413-8670 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16077 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Meningite asséptica | pt_BR |
| Subject in Portuguese | Bactéria | pt_BR |
| Subject in Portuguese | Inflamação das meninges | pt_BR |
| Subject in Portuguese | Fator Estimulador de Colônias de Macrófagos | pt_BR |
| Subject in Portuguese | Interleucina-6 | pt_BR |
| Subject in Portuguese | Interleucina-8 | pt_BR |
| Title | IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis | pt_BR |
| Type | Article | |
| Abstract | Cytokines are molecules that act as mediators of immune response; cerebral spinal fluid (CSF) IL-6 is
found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis
(ABM). A case control study was done to ascertain the discriminatory power of these cytokines in
differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested
through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty
patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA
and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were
increased both in MA and ABM patients (p < 0.05). CSF IL-8 levels were higher in ABM than in AM
and controls (p < 0.05). Discriminatory power in ABM as assessed by the area under receiver operator
(ROC) curve was 0.951 for IL-8, using a cut-off of 1.685 ng/dL (100% of sensitivity and 94% of
specificity). The CSF concentration of both IL-6 and IL-8 are increased in the presence of meningeal
inflammation, IL-8 could be an important tool to differentiate ABM from AM. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Brasília, DF, Brasil / Univbersidade de Brasília. Brasília, DF, Brasil | pt_BR |
| Affilliation | Instituto São Sebastião de Doenças Infecciosas. Laboratório de Referência em Meningite. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | CSF | pt_BR |
| Subject | inflammation meningitis | pt_BR |
| Subject | aseptic meningitis | pt_BR |
| Subject | bacteria | pt_BR |
| Subject | IL-6 | pt_BR |
| Subject | IL-8 | pt_BR |
| e-ISSN | 1678-4391 | |
| Embargo date | 2030-01-01 | |
