| Author | Freitas, Elisangela Oliveira de | |
| Author | Leoratti, Fabiana Maria de Souza | |
| Author | Freire-de-Lima, Célio Geraldo | |
| Author | Morrot, Alexandre | |
| Author | Feijó, Daniel Ferreira | |
| Access date | 2016-10-14T18:13:47Z | |
| Available date | 2016-10-14T18:13:47Z | |
| Document date | 2016 | |
| Citation | FREITAS, E. O. et al. The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis. Frontiers in Immunology, v. 7, p. 1-7, 2016 | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16250 | |
| Sponsorship | CNPq e FAPERJ | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Tratamento | pt_BR |
| Subject in Portuguese | Leishmania donovani | pt_BR |
| Subject in Portuguese | Leishmaniose Visceral | pt_BR |
| Subject in Portuguese | Mecanismos de evasão imune | pt_BR |
| Subject in Portuguese | Protozoários | pt_BR |
| Title | The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3389/fimmu.2016.00153 | |
| Abstract | Leishmania is a genus of protozoan parasites that give rise to a range of diseases called Leishmaniasis that affects annually an estimated 1.3 million people from 88 countries. Leishmania donovani and Leishmania (L.) infantum chagasi are responsible to cause the visceral leishmaniasis. The parasite can use assorted strategies to interfere with the host homeostasis to establish persistent infections that without treatment can be lethal. In this review, we highlight the mechanisms involved in the parasite subversion of the host protective immune response and how alterations of host tissue physiology and vascular remodeling during VL could affect the organ-specific immunity against Leishmania parasites. | pt_BR |
| Affilliation | University of Oxford. The Jenner Institute. Oxford, UK | pt_BR |
| Affilliation | University of Oxford. The Jenner Institute. Oxford, UK | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Laboratorio de Biologia do Sistema Imune. Instituto de Microbiologia. Departmento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Treatment | pt_BR |
| Subject | Leishmania donovani | pt_BR |
| Subject | Host protective responses | pt_BR |
| Subject | Immune evasive mechanisms | pt_BR |
