| Author | Rossaneis, A. C. | |
| Author | Genaro, K. | |
| Author | Dias, Q. M. | |
| Author | Guethe, L. M. | |
| Author | Fais, R. S. | |
| Author | Del Bel, E. A. | |
| Author | Prado, Wiliam. A. | |
| Access date | 2016-11-30T19:13:07Z | |
| Available date | 2016-11-30T19:13:07Z | |
| Document date | 2015 | |
| Citation | ROSSANEIS, A. C. et al. Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats. European Journal of Pain, London, v. 19, p. 1148-1157, Sept. 2015. | pt_BR |
| ISSN | 1090-3801 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16393 | |
| Language | eng | pt_BR |
| Publisher | European Journal of Pain | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Núcleo | pt_BR |
| Subject in Portuguese | Neuropático | pt_BR |
| Subject in Portuguese | Ratos | pt_BR |
| Title | Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats | pt_BR |
| Type | Article | |
| DOI | DOI:10.1002/ejp.638 | |
| Abstract | Background: The anterior pretectal nucleus (APtN) activates descendingmechanisms of pain control. This study evaluated whether the APtN alsocontrols neuropathic pain in rats.Methods: The hypersensitivity to mechanical stimulation with anelectronic von Frey apparatus and the number of Fos-immunoreactive(Fos-ir) neurons in the APtN were evaluated in rats before and afterchronic constriction injury of the sciatic nerve.Results: The tactile hypersensitivity was characterized by an initial phase(the 2 days following the injury) and a maintenance phase (thesubsequent 7 days). The injection of 2% lidocaine (0.25 μL) orN-methyl-D-aspartate (2.5 μg/0.25 μL) into the APtN intensified thetactile hypersensitivity observed 2 days after injury but did not alter thetactile hypersensitivity observed 7 and 14 days after injury. The injection ofnaloxone (10 ng/0.25 μL) or methysergide (40 pg/0.25 μL) but notatropine (100 ng/0.25 μL) into the APtN also intensified the tactilehypersensitivity observed 2 days after the injury. A significant increase inthe number of Fos-ir cells was found in the contralateral APtN 2 days butnot 7 or 14 days after the injury. Electrical stimulation of the APtN reducedthe tactile hypersensitivity at 2, 7 and 14 days after the nerve ligation.Conclusion: APtN exerts a tonic inhibitory influence on persistent pain.The results point out to an important role of opioid and serotonergicmediation into the APtN to inhibit hyperalgesia during the initial phase ofneuropathic pain. | pt_BR |
| Affilliation | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation, Fiocruz Rondônia, Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Department of Morphology, Estomatology and Physiology, Faculty of Odontology of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
| Affilliation | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
| Subject | Nucleus | pt_BR |
| Subject | Neuropathic | pt_BR |
| Subject | Rats | pt_BR |
