| Author | Gusatti, Carolina de Souza | |
| Author | Costi, Cintia | |
| Author | Medeiros, Rúbia Marília de | |
| Author | Halon, Maria Laura | |
| Author | Grandi, Tarciana | |
| Author | Medeiros, Arlete Ferrari Rech | |
| Author | Silva, Cláudia Maria Dornelles da | |
| Author | Rodenbusch, Rodrigo | |
| Author | Silva, Márcia Susana Nunes | |
| Author | Niel, Christian | |
| Author | Rossetti, Maria Lucia Rosa | |
| Access date | 2016-12-01T16:09:01Z | |
| Available date | 2016-12-01T16:09:01Z | |
| Document date | 2016 | |
| Citation | GUSATTI, Carolina de Souza; et al. Association Between Cytokine Gene Polymorphisms and Outcome of Hepatitis B Virus Infection in Southern Brazil. J. Med. Virol., v.88, p.1759–1766, 2016. | pt_BR |
| ISSN | 0146-6615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16405 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Vírus da Hepatite B | pt_BR |
| Subject in Portuguese | cronicidade | pt_BR |
| Subject in Portuguese | Resposta Imune | pt_BR |
| Subject in Portuguese | Desfecho clínico | pt_BR |
| Subject in Portuguese | Polimorfismos do gene da citoquina | pt_BR |
| Title | Association between cytokine gene polymorphisms and outcome of hepatitis B virus infection in southern Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1002/jmv.24518 | |
| Abstract | A number of studies have demonstrated associations between cytokine gene polymorphisms and outcome of hepatitis B virus (HBV) infection. However, no general consensus has been reached, possibly due to differences between ethnic groups. In this study, 345 individuals living in southern Brazil, including 196 chronic HBV carriers and 149 subjects who had spontaneously recovered from acute infection, were enrolled to evaluate the influence of cytokine gene polymorphisms on the outcome of HBV infection. Most participants were of European descent. Genotyping of IL2-330 G/T, IL4-589C/T, IL6-174 G/C, IL10-592C/A, IL10-1082 A/G, IL17A-197 G/A, IL17A-692 T/C, TNF-α-238 G/A, and TNF-α-308 G/A single nucleotide polymorphisms was performed by using the minisequencing (single base extension) method. By multivariable analysis, a statistically significant association was found between genotypic profile AA + GA in TNF-α-308 and chronic HBV infection (OR, 1.82; 95%CI, 1.01-3.27; P = 0.046). In southern Brazil, the carriers of the -308A allele in the TNF-α gene promoter have a moderately higher risk of becoming chronic carriers in case of HBV infection. In addition, patients with chronic active hepatitis B (n = 60) exhibited a decreased frequency (3.3%) of the TNF-238A allele when compared to that (14.8%) found among asymptomatic HBV carriers (n = 136), suggesting that this could be a protective factor against liver injury (OR, 0.17; 95%CI, 0.04-0.076; P = 0.023). J. Med. Virol. 88:1759-1766, 2016. © 2016 Wiley Periodicals, Inc. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Curso de Pós-Graduação em Biologia Celular e Molecular. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul.. Curso de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Departamento Municipal de Saúde. Seção de Hepatite Viral. Chapecó, SC, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Luterana do Brasil. Curso de ós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. C | pt_BR |
| Subject | clinical outcome | pt_BR |
| Subject | HBV | pt_BR |
| Subject | immune response | pt_BR |
| Subject | SNP | pt_BR |
| e-ISSN | 1096-9071 | |
| Embargo date | 2030-01-01 | |
