| Author | Nascimento, Alessandro R. | |
| Author | Machado, Marcus V. | |
| Author | Gomes, Fabiana | |
| Author | Vieira, Aline B. | |
| Author | Albuquerque, Cassiano F. Gonçalves de | |
| Author | Lessa, Marcos A. | |
| Author | Bousquet, Pascal | |
| Author | Tibiriçá, Eduardo | |
| Access date | 2016-12-06T11:29:39Z | |
| Available date | 2016-12-06T11:29:39Z | |
| Document date | 2016 | |
| Citation | NASCIMENTO, Alessandro R. et al. Central Sympathetic Modulation Reverses Microvascular Alterations in a Rat Model of High-Fat Diet-Induced Metabolic Syndrome. Microcirculation, v.23, p. 320–329, 2016. | pt_BR |
| ISSN | 1073-9688 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16432 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Receptores de imidazolina | pt_BR |
| Subject in Portuguese | Hiperatividade simpática | pt_BR |
| Subject in Portuguese | Rarefação microvascular | pt_BR |
| Subject in Portuguese | Microscopia de Vídeo | pt_BR |
| Title | Central Sympathetic Modulation Reverses Microvascular Alterations in a Rat Model of High-Fat Diet-Induced Metabolic Syndrome | pt_BR |
| Type | Article | |
| DOI | 10.1111/micc.12280 | |
| Abstract | Objectives: The objective of this study was to investigate the role
of the SNS on hemodynamic, metabolic, and microvascular
alterations in a rat model of HFD-induced MS with salt supplementation.
Methods: In total, 40 adult male Wistar rats were fed normal chow
(n = 10) or a HFD (n = 30) for 20 weeks. Thereafter, the HFD
group received the centrally acting sympatho-modulatory drugs
clonidine (0.1 mg/kg) or rilmenidine (1 mg/kg) or vehicle (n = 10/
group) orally by gavage. FCD was evaluated using intravital video
microscopy, and the SCD was evaluated using histochemical
analysis.
Results: The pharmacological modulation of the SNS induced
concomitant reductions in SBP, HR and plasma catecholamine
levels. These effects were accompanied by a reversal of functional
and structural capillary rarefaction in the skeletal muscle in both
treated groups and an increase in SCD in the left ventricle only in
the rilmenidine group. Improvement of the lipid profile and of
glucose intolerance was also obtained only with rilmenidine
treatment.
Conclusions: Modulation of sympathetic overactivity results in the
reversal of microvascular rarefaction in the skeletal muscle and left
ventricle and improves metabolic parameters in an experimental
model of MS in rats. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil / University of Strasbourg. Faculty of Medicine. Laboratory of Neurobiology and Cardiovascular Pharmacology, EA 7296. Strasbourg, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil.. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | University of Strasbourg. Faculty of Medicine. Laboratory of Neurobiology and Cardiovascular Pharmacology, EA 7296. Strasbourg, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | imidazoline receptors | pt_BR |
| Subject | intravital video microscopy | pt_BR |
| Subject | microvascular rarefaction | pt_BR |
| Subject | sympathetic overactivity | pt_BR |
| e-ISSN | 1549-8719 | |
| Embargo date | 2030-01-01 | |
