| Author | Andrade, Zilton de Araújo | |
| Author | Andrade, Sonia Gumes | |
| Author | Sadigursky, Moysés | |
| Access date | 2016-12-06T16:54:52Z | |
| Available date | 2016-12-06T16:54:52Z | |
| Document date | 1984 | |
| Citation | ANDRADE, Z. A.; ANDRADE, S. G.; SADIGURSKI, M. Damage and healing in the conducting tissue of the heart (an experimental study in dogs infected with Trypanosoma Cruzi). Journal of Pathology, v. 143, p. 93-101, 1984. | pt_BR |
| ISSN | 0022-3417 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16448 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Miocardite | pt_BR |
| Subject in Portuguese | Tecido condutor | pt_BR |
| Title | Damage and healing in the conducting tissue of the heart (an experimental study in dogs infected with Trypanosoma Cruzi) | pt_BR |
| Type | Article | pt_BR |
| Abstract | The consequences of acute inflammatory damage and chronic repair in the conducting system of the canine heart
were observed after experimental Trypanosoma cruzi infection of young dogs. Acute infection lasted for 18-25 days
and caused hyaline and lytic necrosis of the atrio-ventricular conducting fibres, the sinus node and the neurons in the
cardiac para-sympathetic ganglia. Dogs that survived acute disease were examined after periods from 8 months to 3
years. Three main types of healing were found in the conducting system: fibrosis (diffuse and/or focal),
sclero-atrophy and fatty infiltration. No signs of active chronic inflammation were present, although small focal
residual accumulations of mononuclear cells were present in some animals. No evident electrocardiographic
alterations were elicited by the presence of such cicatricial lesions. The animal model appears worthwhile for the
study of the healing process in conducting tissue of the heart and for the better understanding of the asymptomatic
phase of T. cruzi infection in man. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Subject | Conducting tissue | pt_BR |
| Subject | Chagas’ disease | pt_BR |
| Subject | Myocarditis | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
