| Author | Gonçalves, Rozana Oliveira | |
| Author | Melo, Neli de Almeida | |
| Author | Rêgo, Marco Antônio Vasconcelos | |
| Access date | 2016-12-06T19:10:19Z | |
| Available date | 2016-12-06T19:10:19Z | |
| Document date | 2016 | |
| Citation | GONÇALVES, R. O.; MELO, N. A.; RÊGO, M. A. V. Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure. Environmental Monitoring and Assessment, v. 188, p. 334, 2016. | pt_BR |
| ISSN | 0167-6369 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16457 | |
| Sponsorship | The National Council for Scientific and Technological Development—CNPq (process number 478-068-2003-4), the Gonçalo Moniz Research Center, and the Health Department of the State of Bahia/Workers Health Study Center–CESAT | pt_BR |
| Language | eng | pt_BR |
| Publisher | Springer Verlag | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Exposição profissional | pt_BR |
| Subject in Portuguese | Benzeno Aberrações cromossómicas | pt_BR |
| Subject in Portuguese | Aneuploidia | pt_BR |
| Title | Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s10661-016-5340-1 | |
| Abstract | We aimed to investigate the association between chronic exposure to benzene and genotoxicity in the lymphocytes of workers removed from exposure. The study included 20 workers with hematological disorders who had previously worked in the petrochemical industry of Salvador, Bahia, Brazil; 16 workers without occupational exposure to benzene served as the control group. Chromosomal analysis was performed on lymphocytes from peripheral blood, to assess chromosomal breaks and gaps and to identify aneuploidy. The Kruskal-Wallis test was used to compare the mean values between two groups, and Student's t test for comparison of two independent means. The frequency of gaps was statistically higher in and the exposed group than in the controls (2.13 ± 2.86 vs. 0.97 ± 1.27, p = 0.001). The frequency of chromosomal breaks was significantly higher among cases (0.21 ± 0.58) than among controls (0.12 ± 0.4) (p = 0.0002). An association was observed between chromosomal gaps and breaks and occupational exposure to benzene. Our study showed that even when removed from exposure for several years, workers still demonstrated genotoxic damage. Studies are still needed to clarify the long-term genotoxic potential of benzene after removal from exposure. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University Bahia. Department of Preventive and Social. Salvador, BA, Brasil | pt_BR |
| Subject | Occupational exposure | pt_BR |
| Subject | Benzene Chromosomal aberrations | pt_BR |
| Subject | Aneuploidy | pt_BR |
