| Author | Nunes, Priscila Conrado Guerra | |
| Author | Sampaio, Simone Alves Faria | |
| Author | Costa, Nieli Rodrigues da | |
| Author | Mendonça, Marcos Cesar Lima de | |
| Author | Lima, Monique da Rocha Queiroz | |
| Author | Saraiva, Eliane M. Araujo | |
| Author | Santos, Flávia Barreto dos | |
| Author | Simões, Jaqueline Basto Santos | |
| Author | Gonçalves, Bianca de Santis | |
| Author | Nogueira, Rita Maria Ribeiro | |
| Author | Filippis, Ana Maria Bispo de | |
| Access date | 2016-12-08T14:46:56Z | |
| Available date | 2016-12-08T14:46:56Z | |
| Document date | 2016 | |
| Citation | NUNES, Priscila Conrado Guerra; et al. Dengue Severity Associated With Age and a New Lineage of Dengue Virus-Type 2 During an Outbreak in Rio De Janeiro, Brazil. Journal of Medical Virology, v.88, p.1130–1136, 2016. | pt_BR |
| ISSN | 0146-6615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16485 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Dengue Virus-Type 2 | pt_BR |
| Subject in Portuguese | Viremia | pt_BR |
| Subject in Portuguese | Genótipo | pt_BR |
| Subject in Portuguese | Surtos de dengue | pt_BR |
| Subject in Portuguese | Rio de Janeiro | pt_BR |
| Title | Dengue severity associated with age and a new lineage of dengue virus-type 2 during an outbreak in Rio De Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1002/jmv.24464 | |
| Abstract | Dengue virus-type 2 (DENV-2) caused three outbreaks, in the years 1990, 1998, and 2008, in Rio de Janeiro, Brazil. The 2008 outbreak was the most severe in reported cases, hospitalizations, and deaths. To investigate virological and epidemiological factors that may have contributed to the pathogenic profile of 2008 epidemic, 102 patients sera obtained during the epidemic and inter-epidemic periods of three outbreaks were analysed by qRT-PCR to estimate viremia levels and their correlation with the clinical, immunological, and demographic patient characteristics. DENV-2 isolates from the outbreaks were sequenced. Two DENV-2 lineages (I and II) of the American/Asian genotype were confirmed, each exclusive for 1990-2002 and 2007-2011, respectively. The mean viremia level in the 2008 samples was two orders of magnitude higher than that of the 1990-2002 samples. Severe dengue cases increased from 31% in 1990-2002 to 69% in 2007-2011; in patients aged ≤15 years, from 3% in 1990-2002 to 37% in 2007-2011. The DENV-2 lineage II and younger age significantly contributed to the pathogenic profile of 2008 epidemic in Rio de Janeiro. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | viremia | pt_BR |
| Subject | qRT-PCR | pt_BR |
| Subject | genotype | pt_BR |
| Subject | dengue outbreaks | pt_BR |
| Subject | Rio de Janeiro | pt_BR |
| e-ISSN | 1096-9071 | |
| Embargo date | 2030-01-01 | |
