| Author | Ampah, Kobina Assan | |
| Author | Nascimento, Carlos Augusto Pinho | |
| Author | Kerber, Sarah | |
| Author | Asare, Prince | |
| Author | De-Graft, Daniel | |
| Author | Adu-Nti, Frank | |
| Author | Paixão, Izabel C. N. P. | |
| Author | Niel, Christian | |
| Author | Yeboah-Manu, Dorothy | |
| Author | Pluschke, Gerd | |
| Author | Röltgen, Katharina | |
| Access date | 2016-12-15T11:58:38Z | |
| Available date | 2016-12-15T11:58:38Z | |
| Document date | 2016 | |
| Citation | AMPAH, Kobina Assan; et al. Limited Genetic Diversity of Hepatitis B Virus in the General Population of the Offin River Valley in Ghana. Plos One, v.11, n.6, e0156864, 16p, June 2016. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16539 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vírus da Hepatite B | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Diversidade genética | pt_BR |
| Subject in Portuguese | Gana | pt_BR |
| Title | Limited Genetic Diversity of Hepatitis B Virus in the General Population of the Offin River Valley in Ghana | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0156864 | |
| Abstract | Hepatitis B virus (HBV) infections account for approximately 780,000 deaths per year, most of which occur in the developing world. Co-infection with HBV and hepatitis delta virus (HDV) may lead to the most severe form of viral hepatitis. In Ghana, knowledge on the prevalence of HBV and HDV in the general population is scanty and the few genetic analyses of the prevailing HBV genotypes are dating back more than a decade. In the present study, 1,323 serum samples from individuals living in a rural area (Offin river valley) of Ghana were analyzed for the presence of the hepatitis B surface antigen (HBsAg). Positive sera were subsequently tested for the presence of anti-HDV antibodies. A total of 107 (8%) sera were HBsAg positive with an 8.4% prevalence of anti-HDV antibodies among the HBsAg positives. Phylogenetic analysis based on HBV pre-S/S sequences, attributed all 52 typable samples to genotype E. All belonged to serotype ayw4. While 19 sequences clustered with those from a number of African countries, the other 33 formed a separate cluster distinguished by an intergroup mean distance of 1.5% from the pan-African HBV/E cluster. Successful implementation of HBV vaccination in the region was reflected by the low HBsAg carrier rate of 1.8% among children ≤11 years. | pt_BR |
| Affilliation | Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland / University of Ghana. Noguchi Memorial Institute for Medical Research. Legon, Ghana. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Virologia Molecular. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland. | pt_BR |
| Affilliation | University of Ghana. Noguchi Memorial Institute for Medical Research. Legon, Ghana. | pt_BR |
| Affilliation | University of Ghana. Noguchi Memorial Institute for Medical Research. Legon, Ghana. | pt_BR |
| Affilliation | Radford University College. Accra, Ghana. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Virologia Molecular. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | University of Ghana. Noguchi Memorial Institute for Medical Research. Legon, Ghana. | pt_BR |
| Affilliation | Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland. | pt_BR |
| Affilliation | Swiss Tropical and Public Health Institute. Molecular Immunology. Basel, Switzerland / University of Basel. Basel, Switzerland. | pt_BR |
| Subject | Hepatitis B virus (HBV) infections | pt_BR |
| Subject | Genetic Diversity | pt_BR |
| Subject | Ghana | pt_BR |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
