| Author | Oliveira, Juliana Rebouças de | |
| Author | Bouzas, Maiara Lanna Souza Bacelar | |
| Author | Cardoso, Maria Regina Alves | |
| Author | Barral, Aldina Maria Prado | |
| Author | Carvalho, Cristiana Maria Costa Nascimento | |
| Author | Acute Respiratory Infection and Wheeze Study Group Phase I and II | |
| Access date | 2016-12-15T13:27:42Z | |
| Available date | 2016-12-15T13:27:42Z | |
| Document date | 2016 | |
| Citation | OLIVEIRA, J. R. et al. Frequency of complications and the effects of pneumococcalvaccination in young children with acute respiratory tract infection. Vaccine, v. 34, p. 2556–2561, 2016. | pt_BR |
| ISSN | 0264-410X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16543 | |
| Sponsorship | FAPESB Salvador, Brazil | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Vacina conjugada pneumocócica | pt_BR |
| Subject in Portuguese | Crianças | pt_BR |
| Subject in Portuguese | Vírus comum | pt_BR |
| Subject in Portuguese | Vírus | pt_BR |
| Subject in Portuguese | Pneumonia | pt_BR |
| Title | Frequency of complications and the effects of pneumococcal vaccination in young children with acute respiratory tract infection | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.vaccine.2016.04.015 | |
| Abstract | Acute respiratory infection (ARI) is the most frequent reason for children being seen by doctors worldwide. We aimed to estimate the frequency of complications in children aged 6-23 months during ARI episode and to evaluate risk factors present on recruitment associated with complications after the universal implementation of pneumococcal vaccine (PCV10) in our region. Methods: This prospective cohort enrolled children who had shown ARI for up to 7 days and who weresubsequently followed up 14–21 days after, in Salvador, Brazil. Data on recruitment were registered.The vaccine card was personally checked. Complication was defined when hospitalization, pneumonia oracute otitis media (AOM) were informed during the follow-up visit. Pneumonia and AOM were diagnosedby a doctor. Multiple logistic regression analysis was performed.Results: Of 576 children, 422 (73%) returned and 79 (19%; 95%CI: 15–23%) had complications. The meaninterval between admission and follow-up was 23 ± 13 days. Pneumonia (n = 47; 11%), hospitalization(n = 28; 7%), and AOM (n = 17; 4%) were reported. Most of the patients presented one complication(n = 66; 84%) followed by two (n = 13; 16%). Report of fever (92% versus 79%; OR [95%CI]: 2.90 [1.18–7.14]),bird at home (24% versus 14%; OR [95%CI]: 2.13 [1.07–4.26]), ronchi (48% versus 36%; OR [95%CI]: 2.06[1.16–3.67]) or crackles (17% versus 7%; OR [95%CI]: 2.36 [1.04–5.38]) on auscultation were directly asso-ciated with complications whereas PCV10 (59% versus 75%; OR [95%CI]: 0.46 [0.26–0.82]) was inverselyassociated. Bird at home (OR [95%CI]: 5.80 [1.73–19.38]) and ronchi (OR [95%CI]: 6.39 [1.96–20.85]) wereassociated with AOM; PCV10 was inversely associated with AOM (OR [95%CI]: 0.16 [0.05–0.52]). Crackleswere associated with pneumonia (OR [95%CI]: 2.55 [1.01–6.40]).Conclusions: One fifth of the children presented complications. PCV10 was independently associatedwith lower odds of development of AOM. Bird at home and ronchi are risk factors of otitis. Crackles areassociated with pneumonia. | pt_BR |
| Affilliation | Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil | pt_BR |
| Affilliation | São Paulo University. School of Public Health. Department of Epidemiology. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Department of Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Department of Pediatrics. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia School of Medicine. Department of Pediatrics. Salvador, BA, Brasil | pt_BR |
| Subject | Pneumococcal conjugate vaccine | pt_BR |
| Subject | Children | pt_BR |
| Subject | Common cold | pt_BR |
| Subject | Viruses | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
