Author | Souza, Fernando Almeida | |
Author | Cardoso, Flávia de Oliveira | |
Author | Souza, Bruno Vinicius da Conceição | |
Author | Valle, Tânia Zaverucha do | |
Author | Sá, Joicy Cortez de | |
Author | Oliveira, Iara dSantos da Silva | |
Author | Souza, Celeste da Silva Freitas de | |
Author | Tellis, Carla Junqueira Moragas Tellis | |
Author | Chagas, Maria do Socorro Dos Santos | |
Author | Behrens, Maria Dutra | |
Author | Silva, Ana Lúcia Abreu | |
Author | Calabrese, Kátia da Silva | |
Access date | 2016-12-20T11:29:08Z | |
Available date | 2016-12-20T11:29:08Z | |
Document date | 2016 | |
Citation | SOUZA, Fernando Almeida; et al. Morinda citrifolia Linn. Reduces Parasite Load and Modulates Cytokines and Extracellular Matrix Proteins in C57BL/6 Mice Infected with Leishmania (Leishmania) amazonensis. PLoS Negl Trop Dis., v.10, n.8, e0004900, 17p, Aug. 2016. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16557 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Subject in Portuguese | Leishmania amazonensis | pt_BR |
Subject in Portuguese | Atividade antileishmanial | pt_BR |
Title | Morinda citrifolia Linn. Reduces Parasite Load and Modulates Cytokines and Extracellular Matrix Proteins in C57BL/6 Mice Infected with Leishmania (Leishmania) amazonensis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0004900 | |
Abstract | The absence of an effective vaccine and the debilitating chemotherapy for Leishmaniasis demonstrate the need for developing alternative treatments. Several studies conducted with Morinda citrifolia have shown various biological activities, including antileishmanial activity, however its mechanisms of action are unknown. This study aimed to analyze the in vivo activity of M. citrifolia fruit juice (Noni) against Leishmania (Leishmania) amazonensis in C57BL/6 mice. M. citrifolia fruit juice from the Brazilian Amazon has shown the same constitution of other juices produced around the world and liquid chromatography-mass spectrometry analysis identified five compounds: deacetylasperulosidic acid, asperulosidic acid, rutin, nonioside B and nonioside C. Daily intragastric treatment with Noni was carried out after 55 days of L. (L.) amazonensis infection in C57BL/6 mice. Parasitic loads, cytokine and extracellular protein matrix expressions of the lesion site were analyzed by qPCR. Histopathology of the lesion site, lymph nodes and liver were performed to evaluate the inflammatory processes. Cytokines and biochemical parameters of toxicity from sera were also evaluated. The Noni treatment at 500 mg.kg-1.day-1 for 60 days decreased the lesion size and parasitic load in the footpad infected with L. (L.) amazonensis. The site of infection also showed decreased inflammatory infiltrates and decreased cytokine expressions for IL-12, TNF-α, TGF-β and IL-10. On the other hand, Noni treatment enhanced the extracellular matrix protein expressions of collagen IV, fibronectin and laminin in the infected footpad as well collagen I and II, fibronectin and laminin in the mock-infected footpads. No toxicity was observed at the end of treatment. These data show the efficacy of Noni treatment. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Maranhão. Departamento de Patologia. São Luís, MA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Estadual do Maranhão. Departamento de Patologia. São Luís, MA, Brasil. | pt_BR |
Affilliation | Universidade Estadual do Maranhão. Departamento de Patologia. São Luís, MA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Estadual do Maranhão. Departamento de Patologia. São Luís, MA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | M. citrifolia fruit juice (Noni) | pt_BR |
Subject | antileishmanial activity | pt_BR |
Subject | Leishmania (Leishmania) amazonensi | pt_BR |
Subject | Cytokines | pt_BR |
e-ISSN | 1935-2735 | |