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AutorSavino, Wilson
AutorMessias, Carolina V.
AutorCruz, Daniella A. Mendes da
AutorPassos, Pamela
AutorFerreira, Ana Carolina A. F.
AutorNascimento, Osvaldo J.
Fecha de acceso2016-12-26T15:23:14Z
Fecha de disponibilización2016-12-26T15:23:14Z
Fecha de publicación2016
ReferenciaSAVINO, Wilson; et al. Zika Virus Infection in the Elderly: Possible Relationship with Guillain-Barré Syndrome . Gerontology, 6p, dec. 2016.pt_BR
ISSN0304–324Xpt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/16561
Idiomaengpt_BR
EditorKarger Publisherspt_BR
Derechos de autorrestricted access
Palabras clave en PortuguésZika viruspt_BR
Palabras clave en PortuguésAutoimunidadept_BR
Palabras clave en PortuguésSíndrome de Guillain-Barrépt_BR
Palabras clave en PortuguésEnvelhecimentopt_BR
Palabras clave en PortuguésVacinapt_BR
Palabras clave en PortuguésCélulas Tpt_BR
TítuloZika Virus Infection in the Elderly: Possible Relationship with Guillain-Barré Syndromept_BR
Tipo del documentoArticle
DOI10.1159/000453579
Resumen en InglésThe Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or gastrointestinal infectious diseases. Despite being relatively rare, the incidence rate of GBS rises with age, which makes GBS more frequent in the elderly, in whom it is also a more severe disease with slower recovery than in younger patients. Different forms of GBS have been described having diagnostic confirmation of a previous infection with the ZIKV virus. Although we do not have enough evidence that elderly people are a particularly susceptible population to developing GBS following ZIKV infection, this is plausible. We should consider this possibility, particularly taking into account that aging subjects are more susceptible to infections. In this context, a deeper understanding of how the immune system in the elderly functions in relation to ZIKV infection is necessary, as well as an understanding of what kind of alterations of the nervous system such an infection triggers in the elderly, beyond GBS. This will be relevant for better therapeutic interventions and for designing vaccine candidates that can be applied in an aging population, particularly those prone to develop ZIKV-induced autoimmunity.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / National Institute for Science and Technology on Neuroimmunomodultion - INCT. FIOCRUZ. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / National Institute for Science and Technology on Neuroimmunomodultion - INCT. FIOCRUZ. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / National Institute for Science and Technology on Neuroimmunomodultion - INCT. FIOCRUZ. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónUniversidade Federal Fluminense. Departamento de Neurologia. Niterói, RJ, Brasil.pt_BR
AfiliaciónUniversidade Federal Fluminense. Departamento de Neurologia. Niterói, RJ, Brasil.pt_BR
AfiliaciónUniversidade Federal Fluminense. Departamento de Neurologia. Niterói, RJ, Brasil.pt_BR
Palavras clave en InglêsZika viruspt_BR
Palavras clave en InglêsAgingpt_BR
Palavras clave en InglêsGuillain-Barré syndromept_BR
Palavras clave en InglêsAutoimmunitypt_BR
Palavras clave en InglêsVaccinept_BR
Palavras clave en InglêsT Cellspt_BR
Fecha de embargo2030-01-01
xmlui.metadata.dc.subject.ods03 Saúde e Bem-Estar


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