| Author | Oliveira, Marina Pedroso | |
| Author | Lemes, Pollyanne Sousa | |
| Author | Matos, Márcia Alves Dias | |
| Author | Del-Rios, Nativa Helena Alves | |
| Author | Carneiro, Megmar Aparecida Santos | |
| Author | Silva, Ágabo Macedo Costa | |
| Author | Lopes, Carmen Luci Rodrigues | |
| Author | Teles, Sheila Araújo | |
| Author | Aires, Rodrigo Sebba | |
| Author | Lago, Bárbara Vieira | |
| Author | Araujo, Natalia Motta | |
| Author | Martins, Regina Maria Bringel | |
| Access date | 2016-12-27T10:28:01Z | |
| Available date | 2016-12-27T10:28:01Z | |
| Document date | 2016 | |
| Citation | OLIVEIRA, Marina Pedroso; et al. Overt and Occult Hepatitis B Virus Infection Among Treatment-Naıve HIV-Infected Patients in Brazil. Journal of Medical Virology, v.88, p.1222-1229, 2016. | pt_BR |
| ISSN | 0146-6615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16567 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | Hepatite B | pt_BR |
| Subject in Portuguese | Infecção oculta | pt_BR |
| Title | Overt and occult hepatitis B virus infection among treatment-naïve HIV-infected patients in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1002/jmv.24462 | |
| Abstract | Although hepatitis B virus (HBV) and human immunodeficiency virus (HIV) co-infection is common, only few data are available on HBV among HIV patients including occult hepatitis B infection (OBI), regardless of serological markers. This study aims to determine the prevalence of OBI and overall HBV infection, associated factors, HBV genotypes, and surface (S) gene mutations in a population of treatment-naïve HIV-infected patients in Brazil. A cross-sectional study was conducted in treatment-naïve HIV-infected patients in Central Brazil. All samples were tested for HBV serological markers and HBV DNA. Sequence analysis of the S gene and overlapping polymerase gene was preformed. Overall, 25.1% (127/505) of the patients had markers of current or previous HBV infection, which was associated with age over 40 years, history of injection drug use, and homosexual sex. The hepatitis B surface antigen (HBsAg) seroprevalence was 4.9% (25/505). HBV DNA was detected in 39 out of 505 patients: 20 of them were HBsAg-positive and 19 were HBsAg-negative, resulting in an OBI prevalence of 3.8%. Patients with OBI had significantly higher HCV seropositivity rate compared to HBsAg-positive patients. Sequencing of the S gene revealed Y100C, T131N, and D144A mutations. One patient had the M204I and L180M drug-resistance mutations (polymerase). HBV genotypes A (A1, A2), D (D2, D3), and F (F2) were identified. In conclusion, OBI represented almost half of all HBV infections with detectable HBV DNA, suggesting that hepatitis B diagnosis in HIV patients should include in addition to serological markers the detection of HBV DNA. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG). Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG). Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG). Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG). Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG). Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG). Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG).Faculdade de Enfermagem. Goiânia, GO. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG).Faculdade de Enfermagem. Goiânia, GO. Brasil. | pt_BR |
| Affilliation | Hospital de Doenças Tropicais Dr. Anuar Auad. Goiás, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás (UFG). Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO. Brasil. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | hepatitis B | pt_BR |
| Subject | occult infection | pt_BR |
| Subject | HBV DNA | pt_BR |
| e-ISSN | 1096-9071 | |
| Embargo date | 2030-01-01 | |
