| Author | Santos, Anna Claudia Evangelista dos | |
| Author | Heck, Benjamin | |
| Author | Camargo, Beatriz de | |
| Author | Vargas, Fernando Regla | |
| Access date | 2016-12-27T14:04:10Z | |
| Available date | 2016-12-27T14:04:10Z | |
| Document date | 2016 | |
| Citation | SANTOS, Anna Claudia Evangelista dos; et al. Prevalence of Café-au-Lait Spots in children with solid tumors. Genetics and Molecular Biology, v.39, n.2, p.232-238, 2016. | pt_BR |
| ISSN | 1415-4757 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16576 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Genética | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Anormalidades Congênitas | pt_BR |
| Subject in Portuguese | Tumores sólidos pediátricos | pt_BR |
| Subject in Portuguese | Nosologia | pt_BR |
| Title | Prevalence of Café-au-Lait Spots in children with solid tumors | pt_BR |
| Type | Article | |
| DOI | 10.1590/1678-4685-GMB-2015-0024 | |
| Abstract | Cafe-au-lait maculae (CALM) are frequently observed in humans, and usually are present as a solitary spot. Multiple CALMs are present in a smaller fraction of the population and are usually associated with other congenital anomalies as part of many syndromes. Most of these syndromes carry an increased risk of cancer development. Previous studies have indicated that minor congenital anomalies may be more prevalent in children with cancer. We investigated the prevalence of CALMs in two samples of Brazilian patients with childhood solid tumors, totaling 307 individuals. Additionally, 176 school children without diagnosis of cancer, or of a cancer predisposing syndrome, were investigated for the presence of CALMs. The prevalence of solitary CALM was similar in both study groups (18% and 19%) and also in the group of children without cancer. Multiple CALMs were more frequently observed in one of the study groups (Z = 2.1). However, when both groups were analyzed together, the significance disappeared (Z = 1.5). The additional morphological abnormalities in children with multiple CALMs were analyzed and compared to the findings observed in the literature. The nosologic entities associated with CALMs are reviewed. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro (UFRJ). Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | AC Camargo Cancer Center. Departamento de Pediatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | AC Camargo Cancer Center. Departamento de Pediatria. São Paulo, SP, Brasil / Instituto Nacional de Câncer. Departamento de Oncologia Pediátrica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro (UFRJ). Departamento de Genética. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | café-au-lait maculae | pt_BR |
| Subject | pediatric solid tumors | pt_BR |
| Subject | birth defects | pt_BR |
| Subject | nosology | pt_BR |
| e-ISSN | 1678-4685 | |
