| Author | Santos, Thiago André Ramos dos | |
| Author | Silva, Aline Caroline da | |
| Author | Silva, Elany Barbosa | |
| Author | Gomes, Paulo André Teixeira de Moraes | |
| Author | Espíndola, José Wanderlan Pontes | |
| Author | Cardoso, Marcos Veríssimo de Oliveira | |
| Author | Moreira, Diogo Rodrigo Magalhães | |
| Author | Leite, Ana Cristina Lima | |
| Author | Pereira, Valéria R. A. | |
| Access date | 2016-12-29T13:24:03Z | |
| Available date | 2016-12-29T13:24:03Z | |
| Document date | 2016 | |
| Citation | SANTOS, Thiago André Ramos dos et al. Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells. Biomedicine & Pharmacotherapy, v. 82, p. 555–560, Aug. 2016. | pt_BR |
| ISSN | 0753-3322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16596 | |
| Sponsorship | Brazilian National Research Council (CNPq), Research Foundation of Pernambuco State (FACEPE) and
FIOCRUZ. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Desenvolvimento de fármacos | pt_BR |
| Subject in Portuguese | Cancer | pt_BR |
| Subject in Portuguese | Sistema imunitário | pt_BR |
| Subject in Portuguese | Tiadiazóis | pt_BR |
| Subject in Portuguese | Thiosemicarbazones | pt_BR |
| Subject in Portuguese | Morte celular | pt_BR |
| Title | Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.biopha.2016.05.038 | |
| Abstract | Cancer remains a high incidence and mortality disease, causing around 8.2 million of deaths in the last year. Current chemotherapy needs to be expanded, making research for new drugs a necessary task. Immune system modulation is an emerging concept in cancer cell proliferation control. In fact, there are a number of mechanisms underlying the role immune system plays in tumor cells. In this work, we describe the structural design, synthesis, antitumor and immunomodulatory potential of 31 new 1,3-thiazole and thiosemicarbazone compounds. Cisplatin was used as anticancer drug control. Cytotoxicity against J774A.1 macrophages and antitumor activity against HT-29 and Jurkat cells was determined. These 1,3-thiazole and thiosemicarbazone compounds not only exhibited cytotoxicity in cancer cells, but were able to cause irreversible cancer cell damage by inducing necrosis and apoptosis. In addition, these compounds, especially pyridyl-thiazoles compounds, regulated immune factors such as interleukin 10 and tumor necrosis factor, possible by directing immune system in favor of modulating cancer cell proliferation. By examining their pharmacological activity, we were able to identify new potent and selective anticancer compounds. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
| Subject | Drug development | pt_BR |
| Subject | Cancer | pt_BR |
| Subject | Immune system | pt_BR |
| Subject | Thiadiazoles | pt_BR |
| Subject | Thiosemicarbazones | pt_BR |
| Subject | Cell death | pt_BR |
