| Author | Souza, Anselmo | |
| Author | Santos, Silvane | |
| Author | Carvalho, Lucas P | |
| Author | Grassi, Maria Fernanda Rios | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Access date | 2016-12-29T14:25:03Z | |
| Available date | 2016-12-29T14:25:03Z | |
| Document date | 2016 | |
| Citation | SOUZA, A. et al. Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid. Human Immunology, v. 77, p. 674–681, 2016. | pt_BR |
| ISSN | 0198-8859 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16600 | |
| Sponsorship | CNPq (Brazilian Council for Scientific and Technological Development) and the NIH Training Grant R01 AI079238A (EMC). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | HTLV-1 | pt_BR |
| Subject in Portuguese | Anticorpo | pt_BR |
| Subject in Portuguese | Cytokines | pt_BR |
| Subject in Portuguese | Antigenos | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Title | Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.humimm.2016.06.003 | |
| Abstract | T cells from HTLV-1-infected individuals have a decreased ability to proliferate after stimulation with recall antigens. This abnormality may be due to the production of regulatory cytokine or a dysfunctional antigen presentation. The aims of this study were to evaluate the antibody production and cytokine expression by lymphocytes before and after immunization with tetanus toxoid (TT) and to evaluate the immune response of monocytes after stimulation with TT and frequency of dendritic cells (DC) subsets. HTLV-1 carriers (HC) and uninfected controls (UC) with negative serology for TT were immunized with TT, and the antibody titers were determined by ELISA as well as the cell activation markers expression by monocytes. The frequencies of DC subsets were determined by flow cytometry. Following immunization, the IgG anti-TT titers and the frequency of CD4(+) T cells expressing IFN-γ, TNF-α and IL-10 in response to TT were lower in the HC than in the UC. Additionally, monocytes from HC did not exhibit increased HLA-DR expression after stimulation with TT, and presented low numbers of DC subsets, therefore, it's necessary to perform functional studies with antigen-presenting cells. Collectively, our finding suggests that HC present an impairment of the humoral and CD4(+) T cell immune responses after vaccination. | pt_BR |
| Affilliation | Federal University of Bahia. Hospital Professor Edgard Santos. Immunology Service. Salvador, BA, Brasil / National Institute of Science and Technology – Tropical Diseases. INCT-DT. CNPq. Brazil | pt_BR |
| Affilliation | Federal University of Bahia. Hospital Professor Edgard Santos. Immunology Service. Salvador, BA, Brasil / State University of Feira de Santana. Biological Science Department. Feira de Santana, BA, Brasil / National Institute of Science and Technology – Tropical Diseases. INCT-DT. CNPq. Brazil | pt_BR |
| Affilliation | Federal University of Bahia. Hospital Professor Edgard Santos. Immunology Service. Salvador, BA, Brasil | pt_BR |
| Affilliation | Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Hospital Professor Edgard Santos. Immunology Service. Salvador, BA, Brasil / National Institute of Science and Technology – Tropical Diseases. INCT-DT. CNPq. Brazil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | HTLV-1 | pt_BR |
| Subject | Antibody | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Antigen-presenting cells | pt_BR |
| Subject | Recall antigen | pt_BR |
