The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome

University of Liverpool. Institute of Infection and Globa lHealth. lIverpool. UK / University of Liverpool. , National Institute for Health Research. Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool. UK / Walton Centre National Health Service (NHS). Foundation Trust. UK.
University of Liverpool. Institute of Infection and Globa lHealth. lIverpool. UK / University of Liverpool. , National Institute for Health Research. Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool. UK / Alderhey Children’s NHS Foundation Trust. Liverpool, UK.
Public Health England,.London, UK.
Public Health England,.London, UK / Fundação Oswado Cruz. Instituto Oswaldo Cruz. Laboratório de Virus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.
Walton Centre National Health Service (NHS). Foundation Trust; Liverpool, UK.
University of Liverpool. Institute of Infection and Global Health. Liverpool, UK.
University of Manchester. Institute of Population Health. Faculty of Medical and Human Sciences. Centre for Imaging Sciences. Manchester, UK.
University of Manchester. Institute of Population Health. Faculty of Medical and Human Sciences. Centre for Imaging Sciences. Manchester, UK.
Public Health England. Vaccine Evaluation Unit. Manchester, UK.
University of Manchester. Institute of Population Health. Faculty of Medical and Human Sciences. Centre for Imaging Sciences. Manchester, UK.
University of Liverpool. Institute of Infection and Globa lHealth. lIverpool. UK / University of Liverpool. , National Institute for Health Research. Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool. UK / Walton Centre National Health Service (NHS). Foundation Trust. UK.

Abstract

Encephalitis is parenchymal brain inflammation, commonly due to herpes simplex virus (HSV). Key host inflammatory mediators and their relationship to blood-brain barrier (BBB) permeability, neuroimaging changes, and disease outcome are poorly understood.

Keywords in Portuguese

Encefalite
Citocina
barreira hemato - encefálica
Herpes simples
Quimiocina

Keywords

encephalitis
cytokine
chemokine
herpes simplex
blood-brain barrier

Publisher

Oxford University Press

Citation

MICHAEL, Benedict Daniel; et al. The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome . The Journal of Infectious Diseases, v.213, p.1651-1660, May 2016.

DOI

10.1093/infdis/jiv771

ISSN

0022-1899

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/16606

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Copyright

Restricted access

Embargo date

2030-01-01

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