Author | Lima, Alessandra Estrela da Silva | |
Author | Araújo, Márcio Sobreira Silva | |
Author | Soares, Rodrigo Pedro Pinto | |
Author | Ribeiro, Lorena Gabriela Rocha | |
Author | Damasceno, Karine Araújo | |
Author | Costa, A. T. | |
Author | Carvalho, Andrea Teixeira de | |
Author | Martins Filho, Olindo Assis | |
Author | Dantas, Geovanni | |
Access date | 2017-01-04T17:52:44Z | |
Available date | 2017-01-04T17:52:44Z | |
Document date | 2016 | |
Citation | LIMA, Alessandra Estrela da Silva et al. Plasma biomarkers profile of female dogs with mammary carcinoma and its association with clinical and pathological features. Veterinary and Comparative Oncology, v. 14, n.1, p. 88–100, 2016 | pt_BR |
ISSN | 1476-5829 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16715 | |
Language | eng | pt_BR |
Publisher | John Wiley & Sons | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | patologia clinica | pt_BR |
Subject in Portuguese | cancer/metastase | pt_BR |
Title | Plasma biomarkers profile of female dogs with mammary carcinoma and its association with clinical and pathological features | pt_BR |
Type | Article | pt_BR |
Abstract | The immunological biomarkers profiles were evaluated using Luminex as putative measures to monitor canine mammary carcinomas (MCs). Forty female dogs were categorized into benign mixed tumour (MC-BMT = 28) and mammary carcinoma (MC=12). The ascendant biomarker signatures were used to compare the groups. For example, a higher frequency of MC-BMT animals producing IL-6, CXCL-8 and CXCL-10 was observed, whereas for the MC group IL-2 and CXCL-8 were detected. MC-BMT animals without metastasis had an increase in the levels of IL-2, CXCL-8, CXCL-10, IL-6, TNF-α, IL-15 and a decrease in IL-10 and CXCL-8. MC-BMT animals with metastasis showed only an increase in CXCL-10 and a decrease in IL-18. After comparing the ascendant signatures following the presence of metastasis in both groups, a higher frequency of dogs exhibiting IL-10 production was observed. Pearson correlation (P = 0.0273) and receiver operating characteristic (ROC) curve analysis revealed that this pattern was associated with worse outcome and lower survival rates in MC animals. | pt_BR |
Affilliation | Universidade Federal da Bahia. Escola de Medicina Veterinaria. Departamento de Patologia e Clínica. Salvador, BA, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Patologia Geral. Laboratorio de Patologia Comparada. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundacão Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracão. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundacão Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracão. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Escola de Veterinaria. Departamento de Clínica e Cirurgia Veterinarias. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Patologia Geral. Laboratorio de Patologia Comparada. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Escola de Medicina Veterinaria. Departamento de Patologia e Clínica. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundacão Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracão. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundacão Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracão. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Patologia Geral. Laboratorio de Patologia Comparada. Belo Horizonte, MG, Brasil | pt_BR |
Subject | clinical pathology | pt_BR |
Subject | comparative oncology | pt_BR |
Subject | immunology | pt_BR |
Subject | metastasis | pt_BR |
Subject | oncology | pt_BR |
Subject | clinical pathology | pt_BR |
Subject | comparative oncology | pt_BR |
Subject | metastasis | pt_BR |
e-ISSN | 10.1111/vco.12070 | |
Embargo date | 2028-01-01 | |