Author | Martins, Cyro José de Moraes | |
Author | Genelhu, Virginia | |
Author | Sanjuliani, Antonio Felipe | |
Author | Cabello, Pedro Hernan | |
Author | Francischetti, Emílio Antonio | |
Access date | 2017-01-06T13:09:26Z | |
Available date | 2017-01-06T13:09:26Z | |
Document date | 2012 | |
Citation | MARTINS, Cyro José de Moraes; et al. Association between leptin and its soluble receptor with cardiometabolic risk factors in a Brazilian population. Eurpean Journal of Internal Medicine, v.23, p.e131-e135, 2012. | pt_BR |
ISSN | 0953-6205 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16747 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Soluble leptin receptor | pt_BR |
Subject in Portuguese | Síndrome metabólica | pt_BR |
Subject in Portuguese | Fatores de risco cardiometabólico | pt_BR |
Subject in Portuguese | Leptina | pt_BR |
Title | Association between leptin and its soluble receptor with cardiometabolic risk factors in a Brazilian population | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ejim.2012.05.016 | |
Abstract | Background
Most studies evaluating the conjoint effects of leptin and human soluble leptin receptor (hs-LR) on cardiometabolic risk factors have been conducted in well-characterized ethnic groups. We aimed to assess the associations of leptin and hs-LR with the cardiometabolic risk factors that reflect the components of metabolic syndrome (MetS) in a Brazilian population with varying degrees of adiposity.
Methods
This is a cross-sectional analysis of adult subjects (n=173, age 45±12 years, 124 women; body mass index [BMI] 35.6±9.5 kg/m2) for association of leptin and its soluble receptor with cardiometabolic risk factors (glucose, BMI, waist circumference, hip circumference, blood pressure, insulin, cholesterol and triglycerides). Plasma hs-LR was measured by ELISA; insulin and leptin were determined by RIA. Metabolic syndrome was defined by NCEP/ATP III.
Results
Leptin was positively associated with blood pressure, BMI, waist circumference, hip circumference, triglycerides, glucose, insulin and HOMA and inversely correlated with HDL-cholesterol. The hs-LR exhibited inverse relationship with cardiometabolic risk factors (P≤0.006), except for glucose and lipid parameters. Leptin increased, whereas hs-LR decreased, with increasing number of MetS components (P for trend<0.001). In multivariable models, sex, BMI and insulin were independently associated with leptin, whereas age, sex, BMI and systolic blood pressure were the independent correlates of hs-LR.
Conclusion
In a Brazilian population with complex interethnic admixture, levels of hs-LR and leptin were independently associated with systolic blood pressure and insulin, respectively. Leptin increased with increasing number of MetS components. In turn, hs-LR decreased as the number of MetS components increased. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Patofisiologia Clínica e Experimental (CLINEX). Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Patofisiologia Clínica e Experimental (CLINEX). Rio de Janeiro, RJ, Brasil / UNIGRANRIO. Pro-Reitor de Pesquisa. Duque de Caxias, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Patofisiologia Clínica e Experimental (CLINEX). Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Patofisiologia Clínica e Experimental (CLINEX). Rio de Janeiro, RJ, Brasil / UNIGRANRIO. Pro-Reitor de Pesquisa. Duque de Caxias, RJ, Brasil. | pt_BR |
Subject | Soluble leptin receptor | pt_BR |
Subject | Leptin | pt_BR |
Subject | Metabolic syndrome | pt_BR |
Subject | Cardiometabolic risk factors | pt_BR |
e-ISSN | 1879-0828 | |
Embargo date | 2030-01-01 | |