| Author | Coutinho, R. B. G. Azeredo | |
| Author | Matos, D. C. S. | |
| Author | Nery, J. A. C. | |
| Author | Rosalino, C. M. Valete | |
| Author | Mendonça, S. C. F. | |
| Access date | 2017-01-10T11:47:18Z | |
| Available date | 2017-01-10T11:47:18Z | |
| Document date | 2012 | |
| Citation | COUTINHO, R. B. G. Azeredo et al. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection. Brazilian Journal of Medical and Biological Research, v. 45, p. 632-636, 2012. | pt_BR |
| ISSN | 0100-879X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16773 | |
| Language | eng | pt_BR |
| Publisher | Associação Brasileira de Divulgação Científica | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmaniose mucocutânea | pt_BR |
| Subject in Portuguese | Hanseníase | pt_BR |
| Subject in Portuguese | Hanseníase Multibacilar | pt_BR |
| Subject in Portuguese | Leishmania braziliensis | pt_BR |
| Subject in Portuguese | Interferon gama | pt_BR |
| Subject in Portuguese | Interleucina-10 | pt_BR |
| Title | Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0100-879X2012007500073 | |
| Abstract | We have described a case of a patient with an intriguing association of mucocutaneous leishmaniasis with lepromatous leprosy,
two opposite polar forms of these spectral diseases. In the present follow-up study, we investigated the effect of the addition of
Mycobacterium leprae antigens on interferon-gamma (IFN-γ) production in Leishmania antigen-stimulated cultures of peripheral
blood mononuclear cells (PBMC) from this patient. For this purpose, PBMC cultures were stimulated with crude L. braziliensis
and/or M. leprae whole-cell antigen extracts or with concanavalin A. In some experiments, neutralizing anti-human interleukin
(IL)-10 antibodies were added to the cultures. IFN-γ and IL-10 levels in culture supernatants were measured by ELISA. During
active leprosy, M. leprae antigens induced 72.3% suppression of the IFN-γ response to L. braziliensis antigen, and this suppression
was abolished by IL-10 neutralization. Interestingly, the suppressive effect of M. leprae antigen was lost after the cure of
leprosy and the disappearance of this effect was accompanied by exacerbation of mucosal leishmaniasis. Considered together,
these results provide evidence that the concomitant lepromatous leprosy induced an IL-10-mediated regulatory response that
controlled the immunopathology of mucosal leishmaniasis, demonstrating that, in the context of this coinfection, the specific
immune response to one pathogen can influence the immune response to the other pathogen and the clinical course of the
disease caused by it. Our findings may contribute to a better understanding of the Leishmania/M. leprae coinfection and of the
immunopathogenesis of mucosal leishmaniasis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Referência Nacional em Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Interferon-gamma | pt_BR |
| Subject | Interleukin-10 | pt_BR |
| Subject | Mucocutaneous leishmaniasis | pt_BR |
| Subject | Lepromatous leprosy | pt_BR |
| Subject | Leishmania braziliensis | pt_BR |
| Subject | Mycobacterium leprae | pt_BR |
| e-ISSN | 1414-431X | |
