Author | Cardoso, Cynthia C. | |
Author | Pereira, Ana Carla | |
Author | Souza, Vânia N. Brito de | |
Author | Duraes, Sandra M. B. | |
Author | Alves, Marcelo Ribeiro | |
Author | Nery, José Augusto C. | |
Author | Francio, Ângela S. | |
Author | Vanderborght, Patrícia R. | |
Author | Parelli, Francisco P. C. | |
Author | Alter, Andrea | |
Author | Salgado, Jorge Luís | |
Author | Sampaio, Elizabeth P. | |
Author | Santos, Adalberto R. | |
Author | Oliveira, Maria Leide W. R. | |
Author | Sarno, Euzenir N. | |
Author | Schurr, Erwin | |
Author | Mira, Marcelo T. | |
Author | Pacheco, Antonio G. | |
Author | Moraes, Milton O. | |
Access date | 2017-01-10T14:07:31Z | |
Available date | 2017-01-10T14:07:31Z | |
Document date | 2011 | |
Citation | CARDOSO, Cynthia C. et al. TNF -308G.A Single Nucleotide Polymorphism Is Associated With Leprosy Among Brazilians: A Genetic Epidemiology Assessment, Meta-Analysis, and Functional Study. Journal of Infectious Diseases, v.204, p.1256-1263, Oct. 2011. | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16778 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Hanseníase | pt_BR |
Subject in Portuguese | TNF -308G | pt_BR |
Subject in Portuguese | Polimorfismo Nucleotídico | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study | pt_BR |
Type | Article | |
DOI | 10.1093/infdis/jir521 | |
Abstract | Leprosy is an infectious disease caused by Mycobacterium leprae. Tumor necrosis factor (TNF) plays a key role in the host response. Some association studies have implicated the single nucleotide polymorphism TNF -308G>A in leprosy susceptibility, but these results are still controversial. We first conducted 4 association studies (2639 individuals) that showed a protective effect of the -308A allele (odds ratio [OR] = 0.77; P = .005). Next, results of a meta-analysis reinforced this association after inclusion of our new data (OR = 0.74; P = .04). Furthermore, a subgroup analysis including only Brazilian studies suggested that the association is specific to this population (OR = 0.63; P = .005). Finally, functional analyses using whole blood cultures showed that patients carrying the -308A allele produced higher TNF levels after lipopolysaccharide (LPS) (6 hours) and M. leprae (3 hours) stimulation. These results reinforce the association between TNF and leprosy and suggest the -308A allele as a marker of disease resistance, especially among Brazilians. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Medicina Cl nica. Serviço de Dermatologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Pontifícia Universidade Católica do Paraná. Centro de Ciências Biológicas e da Saúde. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil / Universidade Estadual Paulista (UNESP). Escola de Medicina de Botucatu. Área de Doenças Tropicais. Botucatu, SP, Brasil. | pt_BR |
Affilliation | McGill University. Departments of Medicine and Human Genetics. Department of Medicine and Human Genetics. Research Institute of the McGill University Health Center. Montreal, Quebec, Canada. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Pós-Graduação em Dermatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | McGill University. Departments of Medicine and Human Genetics. Department of Medicine and Human Genetics. Research Institute of the McGill University Health Center. Montreal, Quebec, Canada. | pt_BR |
Affilliation | Pontifícia Universidade Católica do Paraná. Centro de Ciências Biológicas e da Saúde. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Métodos Quantitativos (Cemeq).. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Leprosy | pt_BR |
Subject | TNF -308G | pt_BR |
Subject | Nucleotide Polymorphism | pt_BR |
Subject | Brazil | pt_BR |
e-ISSN | 1537-6613 | |
Embargo date | 2030-01-01 | |