| Author | Potsch, D. V. | |
| Author | Camacho, L. A. B. | |
| Author | Tuboi, S. | |
| Author | Villar, L. M. | |
| Author | Miguel, J. C. | |
| Author | Ginuíno, C. | |
| Author | Silva, E. F. | |
| Author | Mendonça, R. M. M. | |
| Author | Moreira, R. B. | |
| Author | Barroso, P. F. | |
| Access date | 2017-01-17T14:21:49Z | |
| Available date | 2017-01-17T14:21:49Z | |
| Document date | 2012 | |
| Citation | POTSCH, D. V. et al. Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults. Vaccine, v.30, p.5973-5977, 2012. | pt_BR |
| ISSN | 0264-410X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16866 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Hepatite B | pt_BR |
| Subject in Portuguese | Vacina | pt_BR |
| Subject in Portuguese | Infecção por HIV | pt_BR |
| Subject in Portuguese | Resposta imune | pt_BR |
| Title | Vaccination against hepatitis B with 4-double doses increases response rates and antibodies titers in HIV-infected adults | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.vaccine.2012.07.028 | |
| Abstract | Background: Antibody responses to standard regimens of hepatitis B (HBV) vaccination are lower in HIVinfected
subjects and the best hepatitis B vaccine schedule in this population is not known.
Objective: To assess the immunogenicity and to evaluate predictors of serologic response of a modified
regimen of a HBV recombinant vaccine in a cohort of HIV-infected subjects.
Methods: HIV-infected subjects received 4 doses (40 g) of a recombinant HBV vaccine at 0, 1, 2 and 6
months. Demographic information as well as CD4 cell count and plasma viral load were assessed at baseline.
Protective and strong responses were defined as an anti-HBs titer
≥10 mIU/mL and
≥100 mIU/mL,
respectively and were evaluated one month after the third and the fourth doses.
Results: 163 HIV-infected individuals were evaluated 67 (40%) were male and median age was 37 years.
Median CD4 cell count was 385 cells/mm3 and 113 (70%) had undetectable HIV-1 viral load. Protective
antibody response was observed in 83 and 91% and a strong antibody response was observed in 62 and
80% of the subjects after 3 and 4 doses, respectively.
In a multivariate logistic model undetectable HIV-1 viral load and higher CD4 cell counts were independent
predictors of a strong antibody response after 4 doses. Patients with undetectable HIV viral load
were almost 3 times more likely to have anti-HBs titers above 100 mIU/mL than those with detectable
viral load.
Conclusions: A 4-double-dose regimen of a recombinant HBV vaccine increased response rates and determined
higher antibody titers which may translate in prolonged protection agains HBV. Inclusion of a
fourth dose of HBV vaccine for HIV-infected subjects should be considered in the public health setting. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional Para Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional Para Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional Para Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência Nacional Para Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Hepatitis B vaccination | pt_BR |
| Subject | HIV infection | pt_BR |
| Subject | Immune response | pt_BR |
| e-ISSN | 1873-2518 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
