| Author | Souza, Jaqueline Gontijo de | |
| Author | Fonseca, Flávio Guimarães da | |
| Author | Martins, Marina Lobato | |
| Author | Martins, Camila Pacheco Silveira | |
| Author | Carvalho, Luciana Debortoli de | |
| Author | Reis, Jordana Grazziela Alves Coelho dos | |
| Author | Proietti, Anna Bárbara Freitas Carneiro | |
| Author | Martins Filho, Olindo Assis | |
| Author | GIPH | |
| Author | Stancioli, Edel Figueiredo Barbosa | |
| Access date | 2017-01-24T16:57:20Z | |
| Available date | 2017-01-24T16:57:20Z | |
| Document date | 2011 | |
| Citation | SOUZA, Jaqueline Gontijo de et al. Anti-Tax antibody levels in asymptomatic carriers, oligosymptomatic carriers, patients with rheumatologic disease or with HAM/TSP do not correlate with HTLV-1 proviral load. J Clin Virol., v. 50, n. 1, p. 13-8, 2011. | pt_BR |
| ISSN | 1386-6532 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16921 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Science | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | HTLV-1 | pt_BR |
| Title | Anti-Tax antibody levels in asymptomatic carriers, oligosymptomatic carriers, patients with rheumatologic disease or with HAM/TSP do not correlate with HTLV-1 proviral load | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.jcv.2010.09.007 | |
| Abstract | Background: HTLV-1 infects millions of people around the world and induces myelopathy (HAM/TSP), adult T-cell leukemia (ATL) or other inflammatory or rheumatologic diseases. The host-virus interaction causes asymptomatic carriers to develop HAM/TSP. Biomarkers are needed to predict patients who are at risk for HAM/TSP. Tax is highly immunogenic and is a major target protein recognized by cytotoxic T lymphocytes. Anti-Tax antibodies are involved in HAM/TSP pathogenesis.
Objectives: To assess anti-Tax IgG reactivity with a flow cytometry assay (FCA) using an infection/transfection system with Vaccinia virus and pLW44/Tax-expressing Tax and to correlate the anti-Tax response and the HTLV-1 proviral load.
Study design: : We enrolled 81 individuals: 9 HTLV-1 seronegative (NP) and 72 HTLV-1 positive (23 HTLV-1 asymptomatic carriers (AC), 12 oligosymptomatic patients (OL), 7 with rheumatologic diseases (DR) and 30 with HAM/TSP (HT)). Anti-Tax reactivity was assessed by FCA, and HTLV-1 proviral load was measured with real time PCR.
Results: The HT and DR groups showed greater anti-Tax IgG reactivity (p
Conclusion: These findings suggest that although anti-Tax IgG reactivity and the HTLV-1 proviral load are important marke | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Biologia de Microrganismos Intracelulares. Belo Horizonte, MG, Brasil/Interdisciplinary HTLV Research Group.Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Comparada. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação HEMOMINAS. Belo Horizonte, MG, Brazil/Interdisciplinary HTLV Research Group.Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Biologia de Microrganismos Intracelulares. Belo Horizonte, MG, Brasil/Interdisciplinary HTLV Research Group.Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Biologia de Microrganismos Intracelulares. Belo Horizonte, MG, Brasil/Interdisciplinary HTLV Research Group.Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Biologia de Microrganismos Intracelulares. Belo Horizonte, MG, Brasil/Interdisciplinary HTLV Research Group.Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação HEMOMINAS. Belo Horizonte, MG, Brasil/Interdisciplinary HTLV Research Group.Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/Interdisciplinary HTLV Research Group. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Interdisciplinary HTLV Research Group.Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Biologia de Microrganismos Intracelulares. Belo Horizonte, MG, Brasil/Interdisciplinary HTLV Research Group. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | HTLV-1 | pt_BR |
| Subject | Tax | pt_BR |
| Subject | HAM/TSP | pt_BR |
| Subject | Rheumatologic diseases | pt_BR |
| Embargo date | 2030-01-01 | |
