| Author | Perizzolo, Paulo F. | |
| Author | Dalla Costa, Elis R. | |
| Author | Ribeiro, Andrezza W. | |
| Author | Spies, Fernanda S. | |
| Author | Ribeiro, Marta O. | |
| Author | Dias, Cláudia F. | |
| Author | Unis, Gisela | |
| Author | Silva, Pedro Almeida da | |
| Author | Gomes, Harrison M. | |
| Author | Suffys, Philip N. | |
| Author | Rossetti, Maria Lucia R. | |
| Access date | 2017-01-31T12:18:36Z | |
| Available date | 2017-01-31T12:18:36Z | |
| Document date | 2012 | |
| Citation | PERIZZOLO, Paulo F. et al. Characteristics of multidrug-resistant Mycobacterium tuberculosis in southern Brazil. Tuberculosis, v.92, n.1, p.56-59, Jan. 2012. | pt_BR |
| ISSN | 1472-9792 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17632 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Epidemiologia molecular | pt_BR |
| Subject in Portuguese | Resistência a medicamentos | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Characteristics of multidrug-resistant Mycobacterium tuberculosis in southern Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.tube.2011.09.008 | |
| Abstract | A major threat to tuberculosis (TB) control programs is the emergence of drug resistant Mycobacterium tuberculosis strains that cause TB that cannot be cured by standard anti-TB drug regimens. Because few data exist on MDR-TB in this region of the country, we performed an epidemiologic study that combined conventional and molecular analysis of MDR-TB cases from Rio Grande do Sul (RS) that were diagnosed in this period and included cases that were under treatment with second line drug schemes. Included were 121 MDR cases and sequencing of rpoB and katG showed that 106 (87.6%) strains were mutated in rpoB and 97 (80.2%) in katG. Spoligotyping demonstrated that the LAM genotype was predominant (n = 70, 57.8%) and included the largest group composed by 22 (18.1%) strains with the LAM5 ST93 genotype. Other main genotypes belonged to the families T (n = 22, 18.2%), U family (n = 16, 13.2%), Haarlem (n = 5, 4.1%) and X (n = 1, 0.8%). Genotyping by IS6110-RFLP analysis showed 51 distinct fingerprints, 38 (31.4%) of these observed only once and the other 13 patterns being shared among the rest of the isolates (n = 83, 68.6%). Among the 22 strains that were LAM5 ST93, only two had different IS6110-RFLP genotypes. In conclusion, there exists a high degree of M. Tuberculosis genotype clustering among MDR-TB cases in Rio Grande do Sul. Moreover, we observed a large MDR-TB outbreak. | pt_BR |
| Affilliation | Universidade Luterana do Brasil e ULBRA. Programa de Pós-graduação em Genética e Toxicologia Aplicada. Canoas, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde - FEPPS/SES/RS. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde - FEPPS/SES/RS. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde - FEPPS/SES/RS. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde - FEPPS/SES/RS. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Hospital Sanatório Partenon. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Hospital Sanatório Partenon. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande. Departamento de Patologia. Laboratório de Micobacterias. Rio Grande, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada a Micobactérias, Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada a Micobactérias, Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Luterana do Brasil e ULBRA. Programa de Pós-graduação em Genética e Toxicologia Aplicada. Canoas, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde - FEPPS/SES/RS. Porto Alegre, RS, Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Molecular epidemiology | pt_BR |
| Subject | Multidrug-resistance | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1873-281X | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
