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| Autor | Muys, Bruna Rodrigues | |
| Autor | Lorenzi, Júlio Cesar Cetrulo | |
| Autor | Zanette, Dalila Lucíola | |
| Autor | Bueno, Rafaela de Barros Lima e | |
| Autor | Araújo, Luíza Ferreira de | |
| Autor | Santos, Anemari Ramos Dinarte | |
| Autor | Alves, Cleidson de Pádua | |
| Autor | Ramão, Anelisa | |
| Autor | Molfetta, Greice Andreotti de | |
| Autor | Vidal, Daniel Onofre | |
| Autor | Silva, Wilson Araújo | |
| Fecha de acceso | 2017-02-08T19:30:24Z | |
| Fecha de disponibilización | 2017-02-08T19:30:24Z | |
| Fecha de publicación | 2016 | |
| Referencia | MUYS, B. R. et al. Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line. Plos One, v. 11, n. 3, p. 1-17, 2016. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17753 | |
| Promoción | The National Counsel of Technological and Scientific Development (CNPq), São Paulo Research Foundation (FAPESP); and by Research Support of the University of Sao Paulo, CISBi-NAP/USP. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Public Library of Science | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Linha celular, Tumor | pt_BR |
| Palabras clave en Portugués | Metilação DNA | pt_BR |
| Palabras clave en Portugués | Regulação da Expressão Genética | pt_BR |
| Palabras clave en Portugués | Micro-RNAs | pt_BR |
| Palabras clave en Portugués | Humanos | pt_BR |
| Palabras clave en Portugués | Neoplasma | pt_BR |
| Palabras clave en Portugués | Placenta | pt_BR |
| Palabras clave en Portugués | Gravidez | pt_BR |
| Palabras clave en Portugués | Proteina | pt_BR |
| Palabras clave en Portugués | RNA | pt_BR |
| Palabras clave en Portugués | Reprodução | pt_BR |
| Título | Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1371/journal.pone.0151560 | |
| Resumen en Inglés | LINC00629 and MIR503HG are long intergenic non-coding RNAs (lincRNAs) mapped on chromosome X (Xq26), a region enriched for genes associated with human reproduction. Genes highly expressed in normal reproductive tissues and cancers (CT genes) are well known as potential tumor biomarkers. This study aimed to characterize the structure, expression, function and regulation mechanism of MIR503HG and LINC00629 lincRNAs. According to our data, MIR503HG expression was almost exclusive to placenta and LINC00629 was highly expressed in placenta and other reproductive tissues. Further analysis, using a cancer cell lines panel, showed that MIR503HG and LINC00629 were expressed in 50% and 100% of the cancer cell lines, respectively. MIR503HG was expressed predominantly in the nucleus of JEG-3 choriocarcinoma cells. We observed a positively correlated expression between MIR503HG and LINC00629, and between the lincRNAs and neighboring miRNAs. Also, both LINC00629 and MIR503GH could be negatively regulated by DNA methylation in an indirect way. Additionally, we identified new transcripts for MIR503HG and LINC00629 that are relatively conserved when compared to other primates. Furthermore, we found that overexpression of MIR503HG2 and the three-exon LINC00629 new isoforms decreased invasion and migration potential of JEG-3 tumor cell line. In conclusion, our results suggest that lincRNAs MIR503HG and LINC00629 impaired migration and invasion capacities in a choriocarcinoma in vitro model, indicating a potential role in human reproduction and tumorigenesis. Moreover, the MIR503HG expression pattern found here could indicate a putative new tumor biomarker. | pt_BR |
| Afiliación | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Afiliación | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Afiliación | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Afiliación | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Afiliación | National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Afiliación | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Afiliación | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Afiliación | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Afiliación | Molecular Oncology Research Center. Barretos Cancer Hospital. Barretos, SP, Brazil. | pt_BR |
| Afiliación | University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Regional Blood Center of Ribeirão Preto. Riberão Preto, SP, Brazil / Center for Integrative Systems Biology. Center for Medical Genomics. Ribeirão Preto, SP, Brazil. | pt_BR |
| Palavras clave en Inglês | Cell Line, Tumor | pt_BR |
| Palavras clave en Inglês | DNA Methylation | pt_BR |
| Palavras clave en Inglês | Gene Expression Regulation, Neoplastic | pt_BR |
| Palavras clave en Inglês | MicroRNAs | pt_BR |
| Palavras clave en Inglês | Humans | pt_BR |
| Palavras clave en Inglês | Neoplasm | pt_BR |
| Palavras clave en Inglês | Placenta | pt_BR |
| Palavras clave en Inglês | Pregnancy | pt_BR |
| Palavras clave en Inglês | Protein | pt_BR |
| Palavras clave en Inglês | RNA | pt_BR |
| Palavras clave en Inglês | Reproduction | pt_BR |
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