| Author | Phelan, Jody E | |
| Author | Coll, Francesc | |
| Author | Bergval, Indra | |
| Author | Anthony, Richard M | |
| Author | Warren, Rob | |
| Author | Sampson, Samantha L | |
| Author | Gey van Pittius, Nicolaas C | |
| Author | Glynn, Judith R | |
| Author | Crampin, Amelia C | |
| Author | Alves, Adriana | |
| Author | Bessa, Theolis Costa Barbosa | |
| Author | Campino, Susana | |
| Author | Dheda, Keertan | |
| Author | Grandjean, Louis | |
| Author | Hasan, Rumina | |
| Author | Hasan, Zahra | |
| Author | Miranda, Anabela | |
| Author | Moore, David | |
| Author | Panaiotov, Stefan | |
| Author | Perdigao, Joao | |
| Author | Portugal, Isabel | |
| Author | Sheen, Patricia | |
| Author | Sousa, Erivelton de Oliveira | |
| Author | Streicher, Elizabeth M | |
| Author | van Helden, Paul D | |
| Author | Viveiros, Miguel | |
| Author | Hibberd, Martin L | |
| Author | Pain, Arnab | |
| Author | McNerney, Ruth | |
| Author | Clark, Taane G | |
| Access date | 2017-02-10T16:54:31Z | |
| Available date | 2017-02-10T16:54:31Z | |
| Document date | 2016 | |
| Citation | PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016. | pt_BR |
| ISSN | 1471-2164 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17788 | |
| Sponsorship | Biotechnology and Biological Sciences Research Council | pt_BR |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Mycobacterium tuberculosis | pt_BR |
| Subject in Portuguese | Genoma, Bacteriano | pt_BR |
| Subject in Portuguese | Genomica | pt_BR |
| Subject in Portuguese | Evolução, Molecular | pt_BR |
| Subject in Portuguese | DNA, Bacteriana | pt_BR |
| Subject in Portuguese | Análise de Seqüência, DNA | pt_BR |
| Subject in Portuguese | Genes, Bacteriana | pt_BR |
| Title | Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s12864-016-2467-y | |
| Abstract | Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies. | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel | pt_BR |
| Affilliation | Royal Tropical Institute. KIT Biomedical Research. Amsterdam, Netherlands | pt_BR |
| Affilliation | Royal Tropical Institute. KIT Biomedical Research. Amsterdam, Netherlands | pt_BR |
| Affilliation | Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa. | pt_BR |
| Affilliation | Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa. | pt_BR |
| Affilliation | Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa. | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK / Karonga Prevention Study. Lilongwe, Malawi. | pt_BR |
| Affilliation | National Mycobacterium Reference Laboratory. Porto, Portugal | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel | pt_BR |
| Affilliation | University of Cape Town. Department of Medicine, Lung Infection and Immunity Unit. Division of Pulmonology & UCT Lung Institute. Cape Town, Western Cape, South Africa / University of Cape Town. Institute of Infectious Diseases and Molecular Medicine. Cape Town, Western Cape, South Africa | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / Universidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, Peru | pt_BR |
| Affilliation | The Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, Pakistan | pt_BR |
| Affilliation | The Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, Pakistan | pt_BR |
| Affilliation | National Mycobacterium Reference Laboratory. Porto, Portugal | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel | pt_BR |
| Affilliation | National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria | pt_BR |
| Affilliation | National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria | pt_BR |
| Affilliation | Universidade de Lisboa. Lisbon, Portugal | pt_BR |
| Affilliation | Universidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, Peru | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK | pt_BR |
| Subject | Mycobacterium tuberculosis | pt_BR |
| Subject | Genome, Bacterial | pt_BR |
| Subject | Genomics | pt_BR |
| Subject | Evolution, Molecular | pt_BR |
| Subject | DNA, Bacterial | pt_BR |
| Subject | Sequence Analysis, DNA | pt_BR |
| Subject | Genes, Bacteriano | pt_BR |
