| Author | Macedo, Diego Henrique | |
| Author | Menezes Neto, Armando | |
| Author | Rugani, Jeronimo Marteleto Nunes | |
| Author | Lima, Ana Cristina Vianna Mariano da Rocha | |
| Author | Silva, Soraia O. | |
| Author | Melo, Maria N. | |
| Author | Lye, Lon-Fye | |
| Author | Beverley, Stephen M | |
| Author | Gontijo, Célia Maria Ferreira | |
| Author | Soares, Rodrigo Pedro Pinto | |
| Access date | 2017-02-14T17:36:54Z | |
| Available date | 2017-02-14T17:36:54Z | |
| Document date | 2016 | |
| Citation | MACEDO, Diego Henrique et al. Low frequency of LRV1 in Leishmania braziliensis strains isolated from typical and atypical lesions in the State of Minas Gerais, Brazil. Mol Biochem Parasitol., v, 210, n. 1-2, p. 50-54, 2016. | pt_BR |
| ISSN | 0166-6851 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17812 | |
| Language | eng | pt_BR |
| Publisher | Elsevier B.V. | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Leishmania braziliensis | pt_BR |
| Subject in Portuguese | Leishmaniose cutanea | pt_BR |
| Title | Low frequency of LRV1 in Leishmania braziliensis strains isolated from typical and atypical lesions in the State of Minas Gerais, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.molbiopara.2016.08.005 | |
| Abstract | The double stranded RNA (dsRNA) virus Leishmaniavirus (Totiviridae) was first described in Leishmania guyanensis and L. braziliensis (LRV1), and more recently from L. major and L. aethiopica (LRV2). Parasites bearing LRV1 elicit a higher pro-inflammatory profile, arising through activation of Toll like receptor 3(TLR3) interacting with the viral dsRNA. LRV1 is most common in Leishmania from the Amazon region; however data for other regions of Brazil are more limited. Here we applied PCR tests with validated ‘universal’ LRV1 primers to search for LRV1 in 40 strains of cultured L. braziliensis from several locales within Minas Gerais State, including patients presenting with atypical lesion pathology. All strains were negative however. These data are in agreement with results from other areas of Southeastern Brazil that LRV1 is relatively uncommon. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Washington University School of Medicine. Department of Molecular Microbiology. St. Louis, MO, USA | pt_BR |
| Affilliation | Washington University School of Medicine. Department of Molecular Microbiology. St. Louis, MO, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Leishmania braziliensis | pt_BR |
| Subject | Totiviridae | pt_BR |
| Subject | American cutaneous leishmaniasis | pt_BR |
| Embargo date | 2025-01-01 | |
