| Author | Mathad, Jyoti S. | |
| Author | Gupte, Nikhil | |
| Author | Balagopal, Ashwin | |
| Author | Asmuth, David M. | |
| Author | Hakim, James | |
| Author | Santos, Breno | |
| Author | Riviere, Cynthia | |
| Author | Hosseinipour, Mina | |
| Author | Sugandhavesa, Patcharaphan | |
| Author | Infante, Rosa | |
| Author | Pillay, Sandy | |
| Author | Cardoso, Sandra Wagner | |
| Author | Mwelase, Noluthando | |
| Author | Pawar, Jyoti | |
| Author | Berendes, Sima | |
| Author | Kumarasamy, Nagalingeswaran | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Campbell, Thomas B. | |
| Author | Currier, Judith S. | |
| Author | Cohn, Susan E. | |
| Author | Gupta, Amita | |
| Access date | 2017-02-16T16:52:16Z | |
| Available date | 2017-02-16T16:52:16Z | |
| Document date | 2016 | |
| Citation | MATHAD, Jyoti S. et al. Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation. Journal of Acquired Immune Deficiency Syndromes, v. 73, n. 2, p. 123–129, Oct. 2016. | pt_BR |
| ISSN | 1525-4135 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17845 | |
| Description | The authors thank the Prospective Evaluation of Antiretrovirals in esource-Limited Setting study participants for volunteering their time and efforts. | pt_BR |
| Sponsorship | US National Institute of Allergy and Infectious Diseases (NIAID) of the Institutes of Health (NIH). NIH/NIAID Johns Hopkins Baltimore Washington India HIV Clinical Trials Unit. NIH/National Center for Advancing Translational Sciences. Ujala Foundation. Johns Hopkins Center for AIDS Research and the Gilead Foundation. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Previous version | https://www.arca.fiocruz.br/handle/icict/65937 | |
| Rights | open access | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Ativação imunológica | pt_BR |
| Subject in Portuguese | Sexo | pt_BR |
| Subject in Portuguese | Mulheres | pt_BR |
| Subject in Portuguese | Tratamento antiretroviral | pt_BR |
| Title | Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1097/QAI.0000000000001095 | |
| Abstract | Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon g, tumor necrosis factor (TNF) a, IL-6, IL-18, IFN-g–induced protein 10, C-reactive protein (CRP), lipopolysaccharide, and sCD14] were measured at weeks 0, 24, and 48 after combination antiretroviral therapy (cART) in a random subcohort (n = 215) who achieved virologic suppression in ACTG A5175 (Prospective Evaluation of Antiretrovirals in Resource-Limited Settings). Association between sex and changes in markers postcART was examined using random effects models. Average marker differences and 95% confidence intervals were estimated using multivariable models. Results: At baseline, women had lower median log10 viral load (4.93 vs 5.18 copies per milliliter, P = 0.01), CRP (2.32 vs 4.62 mg/L, P =0.01), detectable lipopolysaccharide (39% vs 55%, P = 0.04), and sCD14 (1.9 vs 2.3 mg/mL, P = 0.06) vs men. By week 48, women had higher interferon g (22.4 vs 14.9 pg/mL, P = 0.05), TNF-a (11.5 vs 9.5pg/mL, P = 0.02), and CD4 (373 vs 323 cells per cubic millimeter, P =0.02). In multivariate analysis, women had greater increases in CD4 and TNF-a but less of a decrease in CRP and sCD14 compared with men. Conclusions: With cART-induced viral suppression, women have less reduction in key markers of inflammation and immune activation compared with men. Future studies should investigate the impact of these sex-specific differences on morbidity and mortality. | pt_BR |
| Affilliation | Weill Cornell Medical College. Center for Global Health. Division of Infectious Diseases. New York, NY, USA. | pt_BR |
| Affilliation | Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, India / Johns Hopkins University School of Medicine. Division of Infectious Diseases. Baltimore, USA. | pt_BR |
| Affilliation | Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, India. | pt_BR |
| Affilliation | University of California Davis Medical Center. Department of Internal Medicine. Division of Infectious Diseases. Sacramento, CA, USA. | pt_BR |
| Affilliation | University of California Davis Medical Center. Department of Internal Medicine. Division of Infectious Diseases. Sacramento, CA, USA. | pt_BR |
| Affilliation | Hospital Nossa Senhora de Conceição. Divisão de Doenças Infecciosas. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Les Centres GHESKIO. Port-Au-Prince, Haiti. | pt_BR |
| Affilliation | University of North Carolina-Lilongwe. Department of Medicine. Lilongwe, Malawi. | pt_BR |
| Affilliation | Research Institute for Health Sciences. Chiang Mai, Thailand. | pt_BR |
| Affilliation | Impacta Peru. San Miguel, Peru. | pt_BR |
| Affilliation | Durban University of Technology. Durban International Clinical Research Site. Durban, South Africa. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Witwatersrand. Department of Medicine. Johannesburg, South Africa. | pt_BR |
| Affilliation | National AIDS Research Institute. Pune, India. | pt_BR |
| Affilliation | Johns Hopkins University Research Project. Malawi College of Medicine. Blantyre, Malawi. | pt_BR |
| Affilliation | Johns Hopkins University Research Project. Malawi College of Medicine. Blantyre, Malawi. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Departamento de Medicina de Investigações. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil. | pt_BR |
| Affilliation | University of Colorado-Denver. Division of Infectious Diseases. Aurora, CO, USA. | pt_BR |
| Affilliation | University of California Los Angeles. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Northwestern University Feinberg School of Medicine. Division of Infectious Diseases. Chicago, USA. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Immune activation | pt_BR |
| Subject | Sex | pt_BR |
| Subject | Women | pt_BR |
| Subject | Antiretroviral treatment | pt_BR |
| DeCS | HIV | pt_BR |
| DeCS | Comportamento Sexual | pt_BR |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
