| Author | Faria, Nieli Rodrigues da Costa | |
| Author | Solorzano, Victor Edgar Fiestas | |
| Author | Nogueira, Rita Maria Ribeiro | |
| Author | Carneiro, Thaís Chouin | |
| Author | Nunes, Priscila Conrado Guerra | |
| Author | Simões, Jaqueline Bastos Santos | |
| Author | Nogueira, Fernanda de Bruycker | |
| Author | Lima, Monique da Rocha Queiroz | |
| Author | Pinto, Luzia Maria de Oliveira | |
| Author | Kubelka, Claire Fernandes | |
| Author | Cunha, Rivaldo Venâncio da | |
| Author | Azeredo, Elzinandes Leal de | |
| Author | Santos, Flávia Barreto dos | |
| Access date | 2017-02-23T12:32:57Z | |
| Available date | 2017-02-23T12:32:57Z | |
| Document date | 2016 | |
| Citation | FARIA, Nieli Rodrigues da Costa et al. Dengue epidemics in two distinct periods reveal distinct epidemiological, laboratorial and clinical aspects in a same scenario: analysis of the 2010 and 2013 epidemics in Mato Grosso do Sul, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 110, n. 4, p. 228–236, Apr. 2016. | pt_BR |
| ISSN | 0035-9203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17888 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Dengue | pt_BR |
| Subject in Portuguese | Aspectos clínicos | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Diagnóstico | pt_BR |
| Subject in Portuguese | Epidemias | pt_BR |
| Subject in Portuguese | NS1 | pt_BR |
| Title | Dengue epidemics in two distinct periods reveal distinct epidemiological, laboratorial and clinical aspects in a same scenario: analysis of the 2010 and 2013 epidemics in Mato Grosso do Sul, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1093/trstmh/trw013 | |
| Abstract | Background: Dengue is a major problem in Brazil. Epidemiological and clinical aspects were characterized in patients from two epidemics which occurred in Mato Grosso do Sul, Brazil. Methods: Dengue cases were classified according to the 2009 WHO criteria, tested by serological and molecular biology tests and analysed for nonstructural protein 1 (NS1) antigenemia. Results: Dengue was confirmed in 78.7% (48/61) and 75.6% (118/156) of the cases studied in 2010 and 2013, respectively. DENV-1 and DENV-2 were the serotypes involved in the 2010 epidemic and DENV-4 in the 2013 one. Most of the cases were classified as dengue without warning; however, severe dengue was observed in 18.7% (9/48) of the cases in 2010 and less observed in DENV-4 cases. NS1 levels were higher in patients with dengue with warning signs and severe dengue in 2010. Circulating aspartate aminotransferase (AST) and alanine transferase (ALT) were altered in all groups, independently of the infecting serotype or epidemic. Patients with DENV-1 and DENV-2 presented significant lower monocyte counts when compared to patients with DENV-4. An inverse correlation was found between platelet count, leucocytes, monocytes and NS1 levels. Conclusions: Epidemics caused by the prevalence of distinct DENV serotypes had different impacts and clinical characteristics in a same scenario and, despite the occurrence of secondary infections, the DENV-4 emergence was not associated with severe cases. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavírus. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Clinical aspects | pt_BR |
| Subject | Dengue virus | pt_BR |
| Subject | Diagnosis | pt_BR |
| Subject | Epidemics | pt_BR |
| Subject | NS1 | pt_BR |
| e-ISSN | 1878-3503 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
