| Author | Seixas, Magda Oliveira | |
| Author | Rocha, Larissa Carneiro | |
| Author | Carvalho, Mauricio Barreto | |
| Author | Menezes, Joelma Figueiredo | |
| Author | Lyra, Isa Menezes | |
| Author | Nascimento, Valma Maria Lopes do | |
| Author | Couto, Ricardo David | |
| Author | Ajax, M. Atta | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Gonçalves, Marilda de Souza | |
| Access date | 2011-03-29T14:22:18Z | |
| Available date | 2011-03-29T14:22:18Z | |
| Document date | 2010 | |
| Citation | SEIXAS, M. O. et al. Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease. Lipids in Health and Diseases, v. 9, p.91, 2010. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/1788 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Title | Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/1476-511X-9-91 | |
| Abstract | BACKGROUND: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steady-state children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, anti-aggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. METHODS: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. RESULTS: Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005), bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001), aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol (P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of cholelithiasis. CONCLUSIONS: We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundacao de Hematologia e Hemoterapia do Estado da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Pediátrico Prof. Hosannah de Oliveira. Salvador, BA, Brasil | pt_BR |
| DeCS | Anemia falciforme | pt_BR |
| DeCS | Colesterol HDL | pt_BR |
| DeCS | Dislipiemias | pt_BR |
| DeCS | Mediadores da Inflamação | pt_BR |
| DeCS | Crianças | pt_BR |
