| Author | Mendes, Fernanda de Souza Nogueira Sardinha | |
| Author | Sousa, Andréa Silvestre | |
| Author | Souza, Fernando Cesar de Castro Cesar | |
| Author | Pinto, Vivian Liane Mattos | |
| Author | Silva, Paula Simplicio | |
| Author | Saraiva, Roberto Magalhães | |
| Author | Xavier, Sergio Salles | |
| Author | Veloso, Henrique Horta | |
| Author | Holanda, Marcelo Teixeira | |
| Author | Costa, Andréa Rodrigues | |
| Author | Carneiro, Fernanda Martins | |
| Author | Silva, Gilberto Marcelo Sperandio | |
| Author | Borges, Juliana Pereira | |
| Author | Tibiriçá, Eduardo | |
| Author | Pinheiro, Roberta Olmo | |
| Author | Lara, Flavio Alves | |
| Author | Hasslocher-Moreno, Alejandro Marcel | |
| Author | Brasil, Pedro Emmanuel Alvarenga Americano | |
| Author | Mediano, Mauro Felippe Felix | |
| Access date | 2017-02-28T14:42:56Z | |
| Available date | 2017-02-28T14:42:56Z | |
| Document date | 2016 | |
| Citation | MENDES, Fernanda de Souza Nogueira Sardinha et al. Effect of physical exercise training in patients with Chagas heart disease: study protocol for a randomized controlled trial (PEACH study). Trials, v. 17, p. 1-11, 2016. | pt_BR |
| ISSN | 1745-6215 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17904 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Doenças de Chagas | pt_BR |
| Subject in Portuguese | Insuficiência cardíaca | pt_BR |
| Subject in Portuguese | Exercício de treinamento | pt_BR |
| Subject in Portuguese | Reabilitação cardíaca | pt_BR |
| Subject in Portuguese | Teste de exercício cardiopulmonar | pt_BR |
| Title | Effect of physical exercise training in patients with Chagas heart disease: study protocol for a randomized controlled trial (PEACH study) | pt_BR |
| Type | Article | |
| DOI | 10.1186/s13063-016-1553-4 | |
| Abstract | Background: The effects of exercise training on Chagas heart disease are still unclear. This study aimed to evaluate the effect of exercise training over functional capacity, cardiac function, quality of life, and biomarkers in Chagas heart disease. Methods: The PEACH study is a superiority randomized clinical trial which will include subjects who meet the following criteria: Chagas heart disease with a left ventricular ejection fraction below 45 % with or without heart failure symptoms; clinical stability in the last 3 months; adherence to clinical treatment; and age above 18 years. The exclusion criteria are: pregnancy; neuromuscular limitations; smoking; evidence of non-chagasic heart disease; systemic conditions that limit exercise practice or cardiopulmonary exercise test; unavailability to attend the center three times a week during the intervention period; and practitioners of regular exercise. The intervention group will perform an exercise training intervention three times per week during 6 months and will be compared to the control group without exercise. Both groups will undergo the same monthly pharmaceutical and nutritional counseling as well as standard medical treatment according to the Brazilian consensus on Chagas disease. The primary outcome is functional capacity based on peak exercise oxygen consumption during cardiopulmonary exercise testing. Secondary outcomes are: cardiac function; body composition; muscle respiratory strength; microvascular reactivity; cardiac rhythm abnormalities; autonomic function; biochemical; oxidative stress and inflammatory biomarkers; and quality of life. Subjects will be evaluated at baseline, and at 3 and 6 months after randomization. Thirty patients will be randomly assigned into exercise or control groups at a ratio of 1:1. Discussion: Findings of the present study will be useful to determine if physical exercise programs should be included as an important additional therapy in the treatment of patients with Chagas heart disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Instituto de Educação Física e Esportes. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evando Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Chagas heart disease | pt_BR |
| Subject | Heart failure | pt_BR |
| Subject | Exercise training | pt_BR |
| Subject | Cardiac rehabilitation | pt_BR |
| Subject | Cardiopulmonary exercise test | pt_BR |
| Embargo date | 2030-12-31 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
