| Author | Vieira, Camilo | |
| Author | Oliveira, Carolina Nogueira Costa de | |
| Author | Figueiredo, Ludmila Araújo Borges de | |
| Author | Santiago, Rayra Pereira | |
| Author | Adanho, Corynne Stephanie Ahouefa | |
| Author | Santana, Sanzio Silva | |
| Author | Burak, Caroline Lang | |
| Author | Lyra, Isa Menezes | |
| Author | Goncalves, Marilda Souza | |
| Access date | 2017-03-07T16:06:20Z | |
| Available date | 2017-03-07T16:06:20Z | |
| Document date | 2016 | |
| Citation | Transcranial Doppler in hemoglobin SC disease. Pediatr Blood & Cancer, p. 1–4, 2016. | pt_BR |
| ISSN | 1545-5009 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17963 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Hemoglobinopatias | pt_BR |
| Subject in Portuguese | Neurologia e anemia falciforme | pt_BR |
| Subject in Portuguese | Doença falciforme | pt_BR |
| Subject in Portuguese | Ultra-som Doppler transcraniano | pt_BR |
| Title | Transcranial Doppler in hemoglobin SC disease | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1002/pbc.26342 | |
| Abstract | Stroke is a severe clinical disorder in sickle cell disease (SCD), and few studies have evaluated transcranial Doppler (TCD) flow velocities in hemoglobin SC disease (HbSC). The guidelines for stroke risk are based on evaluations in sickle cell anemia (SCA) or HbS/β thalassemia. Procedure: In this study, we compare cerebral blood flow in patients with SCD stratified by genotypes.
A total of 1,664 pediatric patients with SCD underwent TCD velocity screening, and the
time-averaged maximum mean velocity (TAMM) was determined in the middle cerebral artery
(MCA), anterior cerebral artery (ACA), and distal intracranial internal carotid artery (ICA) .
Results: Abnormal velocities were not identified in the ACA; therefore, we only use ICA and MCA
velocities. TAMM from the left and right in the ICA andMCA was 134.3 ± 32.0 and 134.4 ± 32.6
cm/s in patients with SCA, and 105.2 ± 20.6 and 104.7 ± 20.0 cm/s in the patients with HbSC,
respectively. Mean TAMM between right and left ICA/MCA was 134.5 ± 30.5 cm/s in the SCA
group, and 104.9 ± 19.3 cm/s in the HbSC group.Notably, our data show that TCDvelocitieswere
significantly lower among the patientswithHbSC compared to SCA. TAMMwas negatively correlated
with hemoglobin and hematocrit in both genotypes.
Conclusion: These results suggest that a different cut-off value for abnormal TCD velocities could
be considered for patients with HbSC. Additional studies are warranted to determine the actual
risk of stroke in HbSC genotype associated with this possible TCD risk value. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Ambulatório Pediátrico de Doença Cerebrovascular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Salvador. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Salvador. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Hematologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Hematologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil | pt_BR |
| Subject | Hemoglobinopathies | pt_BR |
| Subject | Neurology and sickle cell | pt_BR |
| Subject | Sickle cell disease | pt_BR |
| Subject | Transcranial Doppler ultrasound | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
