| Author | Yarmolinsky, James | |
| Author | Mueller, Noel T. | |
| Author | Duncan, Bruce B. | |
| Author | Chor, Dóra | |
| Author | Bensenor, Isabela | |
| Author | Griep, Rosane H. | |
| Author | Appel, Lawrence J. | |
| Author | Barreto, Sandhi M. | |
| Author | Schmidt, Maria Inês | |
| Access date | 2017-03-21T15:34:07Z | |
| Available date | 2017-03-21T15:34:07Z | |
| Document date | 2016 | |
| Citation | YARMOLINSKY, James et al. Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health. Scientific Reports, v. 6, p. 1-9, Nov. 2016. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18102 | |
| Language | eng | pt_BR |
| Publisher | Nature Publishing Group | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Subject in Portuguese | Fatores de Risco | pt_BR |
| Subject in Portuguese | Diabetes Tipo 2 | pt_BR |
| Title | Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1038/srep37032 | |
| Abstract | Emerging evidence suggests sex differences in the early origins of adult metabolic disease, but this has been little investigated in developing countries. We investigated sex-specific associations between low birth weight (LBW; <2.5 kg) and adult-onset diabetes in 12,525 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Diabetes was defined by self-reported information and laboratory measurements. In confounder-adjusted analyses, LBW (vs. 2.5-4 kg) was associated with higher prevalence of diabetes in women (Prevalence Ratio (PR) 1.54, 95% CI: 1.32-1.79), not in men (PR 1.06, 95% CI: 0.91-1.25; Pheterogeneity = 0.003). The association was stronger among participants with maternal diabetes (PR 1.60, 95% CI: 1.35-1.91), than those without (PR 1.15, 95% CI: 0.99-1.32; Pheterogeneity = 0.03). When jointly stratified by sex and maternal diabetes, the association was observed for women with (PR 1.77, 95% CI: 1.37-2.29) and without (PR 1.45, 95% CI: 1.20-1.75) maternal diabetes. In contrast, in men, LBW was associated with diabetes in participants with maternal diabetes (PR 1.45, 95% CI: 1.15-1.83), but not in those without (PR 0.92, 95% CI: 0.74-1.14). These sex-specific findings extended to continuous measures of glucose homeostasis. LBW was associated with higher diabetes prevalence in Brazilian women, and in men with maternal diabetes, suggesting sex-specific intrauterine effects on adult metabolic health. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Escola de Medicina. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, USA / Johns Hopkins University. Welch Center for Prevention, Epidemiology and Clinical Research. Baltimore, MD, USA. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Escola de Medicina. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil / University of North Carolina. Department of Epidemiology. Chapel Hill, NC, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Departamento de Clínica Médica. São Paulo, SP, Brasil / Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, USA / Johns Hopkins University. Welch Center for Prevention, Epidemiology and Clinical Research. Baltimore, MD, USA. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Escola de Medicina. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil / University of North Carolina. Department of Epidemiology. Chapel Hill, NC, USA. | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Risk factors | pt_BR |
| Subject | Type 2 diabetes | pt_BR |
| e-ISSN | 2045-2322 | |
